EMDB EMD-20291

Single particle reconstruction
3.78Å resolution

ZINC17988990-bound TRPV5 in nanodiscs

Map released:
Overview of EMD-20291
Source organism: Oryctolagus cuniculus [9986]
Fitted atomic model: 6pbe
Related EM entry by publication: EMD-20292
Primary publication:
Structure-based characterization of novel TRPV5 inhibitors.
Hughes TE, Del Rosario JS, Kapoor A, Yazici AT, Yudin Y, Fluck EC, Filizola M, Rohacs T, Moiseenkova-Bell VY
Elife 8 - (2019)
PMID: 31647410

Function and Biology Details

Sample name: ZINC17988990-bound TRPV5 in nanodiscs
Ligand: (4-oxo-5-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)methyl 3-(3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)propanoate
Proteins: ZINC17988990-bound TRPV5 in nanodiscs, Transient receptor potential cation channel subfamily V member 5

Experimental Information Details

Resolution: 3.78Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C4
Reconstruction software: RELION
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 SUMMIT (4k x 4k)