EMDB EMD-20239

Single particle reconstruction
3.1Å resolution

Tetrameric structure of ACAT1

Map released:
Last modified:
Overview of EMD-20239
Source organism: Homo sapiens [9606]
Fitted atomic model: 6p2p
Related EM entry by publication: EMD-20238
Primary publication:
Structural basis for catalysis and substrate specificity of human ACAT1.
Qian H, Zhao X, Yan R, Yao X, Gao S, Sun X, Du X, Yang H, Wong CCL, Yan N
Nature 581 333-338 (2020)
PMID: 32433614

Function and Biology Details

Sample name: ACAT1
Ligand: S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name)
Proteins: ACAT1, Sterol O-acyltransferase 1

Experimental Information Details

Resolution: 3.1Å
Resolution method: FSC 0.143 CUT-OFF
Detector: GATAN K2 SUMMIT (4k x 4k)