EMDB EMD-20055

Single particle reconstruction
4.36Å resolution

Cryo-EM structure of Her2 extracellular domain-Trastuzumab Fab-Pertuzumab Fab complex

Map released:
Overview of EMD-20055
Source organism: Homo sapiens [9606]
Fitted atomic model: 6oge
Primary publication:
Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex.
Hao Y, Yu X, Bai Y, McBride HJ, Huang X
Plos One 14 e0216095-e0216095 (2019)
PMID: 31042744

Function and Biology Details

Sample name: Her2 extracellular domain-Trastuzumab Fab-Pertuzumab Fab complex
Ligands: N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ALPHA-D-MANNOSE
Proteins: Her2 extracellular domain-Trastuzumab Fab-Pertuzumab Fab complex, Human HER2 extracellular domain, Pertuzumab Fab, Trastuzumab Fab, Receptor tyrosine-protein kinase erbB-2, Pertuzumab FAB LIGHT CHAIN, Pertuzumab FAB HEAVY CHAIN, Trastuzumab FAB LIGHT CHAIN, Trastuzumab FAB HEAVY CHAIN

Experimental Information Details

Resolution: 4.36Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C1
Reconstruction software: cisTEM
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 SUMMIT (4k x 4k)