EMD-19108

Single-particle
3.6 Å
EMD-19108
3D View Gallery
Deposition: 12/12/2023
Map released: 12/06/2024
Last modified: 21/08/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-19108

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Human TPC2 in Complex withAntagonist (R)-SG-094

EMD-19108

Single-particle
3.6 Å
EMD-19108
3D View Gallery
Deposition: 12/12/2023
Map released: 12/06/2024
Last modified: 21/08/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Homodimeric complex of human Two-pore channel 2 (TPC2)

Deposition Authors: Chi G , Pike ACW, Maclean EM, Li H , Mukhopadhyay SMM, Bohstedt T , Wang D, McKinley G, Fernandez-Cid A, Duerr K
Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist.
Chi G , Jaslan D , Kudrina V , Bock J, Li H , Pike ACW, Rautenberg S, Krogsaeter E, Bohstedt T , Wang D, McKinley G, Fernandez-Cid A, Mukhopadhyay SMM, Burgess-Brown NA, Keller M , Bracher F, Grimm C, Durr KL
(2024) Structure , 32 , 1137 - 1149.e4
PUBMED: 38815576
DOI: doi:10.1016/j.str.2024.05.005
ISSN: 0969-2126
ASTM: STRUE6
Grant Support: