EMD-19000

Single-particle
3.8 Å
EMD-19000
3D View Gallery
Deposition: 29/11/2023
Map released: 13/12/2023
Last modified: 16/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-19000
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Cryo-EM structure of coagulation factor beta-XIIa in complex with the garadacimab Fab fragment (asymmetric dimer)

EMD-19000

Single-particle
3.8 Å
EMD-19000
3D View Gallery
Deposition: 29/11/2023
Map released: 13/12/2023
Last modified: 16/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Ternary complex of coagulation factor beta-XIIa with garadacimab Fab fragment and anti-LC-lambda VHH

Deposition Authors: Drulyte I
Structural basis for the inhibition of beta FXIIa by garadacimab.
Drulyte I , Ghai R, Ow SY, Kapp EA, Quek AJ, Panousis C, Wilson MJ, Nash AD, Pelzing M
(2024) Structure , 32 , 1705 - 1710.e3
PUBMED: 39059382
DOI: doi:10.1016/j.str.2024.07.001
ISSN: 0969-2126
ASTM: STRUE6
Grant Support: