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EMD-16963

Single-particle
2.59 Å
EMD-16963
3D View Gallery
Deposition: 30/03/2023
Map released: 09/08/2023
Last modified: 23/08/2023
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-16963
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3D volume (map.gz) Experimental metadata (xml)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8olu summary report (pdf.gz) Map and 8olu FULL report (pdf.gz)
EMICSS annotations (xml)

Leishmania tarentolae proteasome 20S subunit in complex with 1-Benzyl-N-(3-(cyclopropylcarbamoyl)phenyl)-6-oxo-1,6-dihydropyridazine-3-carboxamide

EMD-16963

Single-particle
2.59 Å
EMD-16963
3D View Gallery
Deposition: 30/03/2023
Map released: 09/08/2023
Last modified: 23/08/2023
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Leishmania tarentolae
Sample: Leishmania tarentolae proteasome 20S subunit in complex with 1-Benzyl-N-(3-(cyclopropylcarbamoyl)phenyl)-6-oxo-1,6-dihydropyridazine-3-carboxamide
Fitted models: 8olu

Deposition Authors: Rowland P
Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors.
Thomas MG , McGonagle K , Rowland P, Robinson DA , Dodd PG, Camino-Diaz I, Campbell L, Cantizani J, Castaneda P, Conn D, Craggs PD, Edwards D , Ferguson L, Fosberry A, Frame L, Goswami P, Hu X, Korczynska J, MacLean L, Martin J , Mutter N, Osuna-Cabello M, Paterson C, Pena I, Pinto EG, Pont C, Riley J, Shishikura Y, Simeons FRC, Stojanovski L, Thomas J, Wrobel K, Young RJ , Zmuda F , Zuccotto F, Read KD , Gilbert IH , Marco M , Miles TJ , Manzano P, De Rycker M
(2023) J Med Chem , 66 , 10413 - 10431
PUBMED: 37506194
DOI: doi:10.1021/acs.jmedchem.3c00582
ISSN: 0022-2623
ASTM: JMCMAR
Grant Support: