EMD-16860
Ivabradine bound to HCN4 channel
EMD-16860
Single-particle3.6 Å
Deposition: 15/03/2023Map released: 14/08/2024
Last modified: 14/08/2024
Sample Organism:
Oryctolagus cuniculus
Sample: HCN4
Fitted models: 8ofi
Deposition Authors: Saponaro A
,
Chaves-Sanjuan A ,
Sharifzadeh AS ,
Clarke OB ,
Marabelli C,
Bolognesi M ,
Thiel G ,
Moroni A
Sample: HCN4
Fitted models: 8ofi
Deposition Authors: Saponaro A
,
Chaves-Sanjuan A ,
Sharifzadeh AS ,
Clarke OB ,
Marabelli C,
Bolognesi M ,
Thiel G ,
Moroni A
Structural determinants of ivabradine block of the open pore of HCN4.
Saponaro A ,
Krumbach JH,
Chaves-Sanjuan A ,
Sharifzadeh AS ,
Porro A ,
Castelli R ,
Hamacher K,
Bolognesi M ,
DiFrancesco D ,
Clarke OB ,
Thiel G ,
Moroni A
(2024) PNAS , 121 , e2402259121 - e2402259121
,
Krumbach JH,
Chaves-Sanjuan A ,
Sharifzadeh AS ,
Porro A ,
Castelli R ,
Hamacher K,
Bolognesi M ,
DiFrancesco D ,
Clarke OB ,
Thiel G ,
Moroni A
(2024) PNAS , 121 , e2402259121 - e2402259121
Grant Support:
- Leducq Foundation: TNE19CVD03 (France)
- Fondazione CARIPLO: 2018-0231 (Italy)
- European Research Council (ERC): ERC Advanced grant noMAGIC 695078 (European Union)
- National Institutes of Health/National Center for Research Resources (NIH/NCRR): NIH grants R01-NS109366 (United States)
- National Institutes of Health/National Center for Research Resources (NIH/NCRR): P41-GM116799 (United States)
- National Institutes of Health/National Center for Research Resources (NIH/NCRR): R01-GM107462 via Type a message (United States)