EMD-16513
human alpha7 nicotinic receptor in complex with the C4 nanobody
EMD-16513
Single-particle2.3 Å
Deposition: 23/01/2023Map released: 11/10/2023
Last modified: 02/07/2025
Sample Organism:
Homo sapiens,
Vicugna pacos huacaya
Sample: Complex of the a7 human nicotinic receptor with the nanobody C4
Fitted models: 8c9x
Deposition Authors: Prevost MS
,
Barilone N,
Dejean de la Batie G,
Pons S,
Ayme G ,
England P ,
Gielen M ,
Bontems F,
Pehau-Arnaudet G ,
Maskos U ,
Lafaye P,
Corringer P-J
Sample: Complex of the a7 human nicotinic receptor with the nanobody C4
Fitted models: 8c9x
Deposition Authors: Prevost MS
,
Barilone N,
Dejean de la Batie G,
Pons S,
Ayme G ,
England P ,
Gielen M ,
Bontems F,
Pehau-Arnaudet G ,
Maskos U ,
Lafaye P,
Corringer P-J
An original potentiating mechanism revealed by the cryo-EM structures of the human alpha 7 nicotinic receptor in complex with nanobodies.
Prevost MS ,
Barilone N,
Dejean de la Batie G,
Pons S,
Ayme G ,
England P ,
Gielen M ,
Bontems F,
Pehau-Arnaudet G ,
Maskos U ,
Lafaye P,
Corringer PJ
(2023) Nat Commun , 14 , 5964 - 5964
,
Barilone N,
Dejean de la Batie G,
Pons S,
Ayme G ,
England P ,
Gielen M ,
Bontems F,
Pehau-Arnaudet G ,
Maskos U ,
Lafaye P,
Corringer PJ
(2023) Nat Commun , 14 , 5964 - 5964
Grant Support:
- European Research Council (ERC): 788974 (European Union)
- Pasteur Institute: (France)
- Centre National de la Recherche Scientifique (CNRS): (France)
- iNEXT-Discovery: (European Union)
- Agence Nationale de la Recherche (ANR): ANR-21-CE37-0026 (France)