EMD-16281

Single-particle
3.32 Å
EMD-16281
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Deposition: 06/12/2022
Map released: 21/02/2024
Last modified: 31/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-16281
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8bw9 summary report (pdf.gz) Map and 8bw9 FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of the RAF activating complex KSR-MEK-CNK-HYP

EMD-16281

Single-particle
3.32 Å
EMD-16281
3D View Gallery
Deposition: 06/12/2022
Map released: 21/02/2024
Last modified: 31/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Drosophila melanogaster
Sample: Quaternary complex of the kinase domains of KSR and MEK bound to the scaffolding complex CNK-HYP
Fitted models: 8bw9

Deposition Authors: Maisonneuve P , Fronzes R , Sicheri F
The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction.
Maisonneuve P , Sahmi M, Bergeron-Labrecque F, Ma XI , Queguiner J, Arseneault G, Lefrancois M, Kurinov I, Fronzes R , Sicheri F , Therrien M
(2024) Nat Struct Mol Biol , 31 , 1028 - 1038
PUBMED: 38388830
DOI: doi:10.1038/s41594-024-01233-6
ISSN: 1545-9985