EMD-16281

Single-particle
3.32 Å
EMD-16281
3D View Gallery
Deposition: 06/12/2022
Map released: 21/02/2024
Last modified: 31/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-16281

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8bw9 summary report (pdf.gz) Map-8bw9 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of the RAF activating complex KSR-MEK-CNK-HYP

EMD-16281

Single-particle
3.32 Å
EMD-16281
3D View Gallery
Deposition: 06/12/2022
Map released: 21/02/2024
Last modified: 31/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Drosophila melanogaster
Sample: Quaternary complex of the kinase domains of KSR and MEK bound to the scaffolding complex CNK-HYP
Fitted models: 8bw9

Deposition Authors: Maisonneuve P , Fronzes R , Sicheri F
The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction.
Maisonneuve P , Sahmi M, Bergeron-Labrecque F, Ma XI , Queguiner J, Arseneault G, Lefrancois M, Kurinov I, Fronzes R , Sicheri F , Therrien M
(2024) Nat Struct Mol Biol , 31 , 1028 - 1038
PUBMED: 38388830
DOI: doi:10.1038/s41594-024-01233-6
ISSN: 1545-9985