EMD-15592
BA.4/5 SARS-CoV-2 Spike bound to mouse ACE2 (local)
EMD-15592
Single-particle3.3 Å
Deposition: 13/08/2022Map released: 15/03/2023
Last modified: 23/10/2024
Sample Organism:
Mus musculus,
Severe acute respiratory syndrome coronavirus 2,
Enterobacteria phage T4
Sample: BA.4/5 SARS-CoV-2 Spike bound to mouse ACE2 (local)
Fitted models: 8aqw
Deposition Authors: Lau K
,
Ni D,
Beckert B,
Nazarov S,
Myasnikov A,
Pojer F,
Stahlberg H ,
Uchikawa E
Sample: BA.4/5 SARS-CoV-2 Spike bound to mouse ACE2 (local)
Fitted models: 8aqw
Deposition Authors: Lau K
,
Ni D,
Beckert B,
Nazarov S,
Myasnikov A,
Pojer F,
Stahlberg H ,
Uchikawa E
Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range.
Ni D,
Turelli P,
Beckert B,
Nazarov S,
Uchikawa E ,
Myasnikov A,
Pojer F,
Trono D,
Stahlberg H ,
Lau K
(2023) PLoS Pathog , 19 , e1011206 - e1011206
,
Myasnikov A,
Pojer F,
Trono D,
Stahlberg H ,
Lau K
(2023) PLoS Pathog , 19 , e1011206 - e1011206
Grant Support:
- Swiss National Science Foundation: NCCR transcure (Switzerland)