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EMD-15520
Cryo-EM structure of human tankyrase 2 SAM-PARP filament (G1032W mutant)
EMD-15520
Helical reconstruction2.98 Å
Deposition: 01/08/2022Map released: 16/11/2022
Last modified: 24/07/2024
Sample Organism:
Homo sapiens
Sample: TNKS2 SAM-PARP (867-1162) filament
Fitted models: 8aly
Deposition Authors: Mariotti L
,
Inian O
,
Desfosses A
,
Beuron F
,
Morris EP,
Guettler S
Sample: TNKS2 SAM-PARP (867-1162) filament
Fitted models: 8aly
Deposition Authors: Mariotti L
,
Inian O
,
Desfosses A
,
Beuron F
,
Morris EP,
Guettler S
Structural basis of tankyrase activation by polymerization.
Pillay N,
Mariotti L
,
Zaleska M,
Inian O
,
Jessop M
,
Hibbs S,
Desfosses A
,
Hopkins PCR
,
Templeton CM,
Beuron F
,
Morris EP,
Guettler S
(2022) Nature , 612 , 162 - 169
,
Zaleska M,
Inian O
,
Jessop M
,
Hibbs S,
Desfosses A
,
Hopkins PCR
,
Templeton CM,
Beuron F
,
Morris EP,
Guettler S
(2022) Nature , 612 , 162 - 169
Grant Support:
- Cancer Research UK: C47521/A28286 (United Kingdom)
- Wellcome Trust: 214311/Z/18/Z (United Kingdom)
- The Institute of Cancer Research (ICR): n.a. (United Kingdom)
- The Lister Institute of Preventive Medicine: n.a. (United Kingdom)
