EMD-15519
human MutSalpha (MSH2/MSH6) on DNA containing a GT mismatch in the presence of ADP
EMD-15519
Single-particle4.1 Å
Deposition: 01/08/2022Map released: 25/01/2023
Last modified: 01/03/2023
Sample Organism:
Homo sapiens,
synthetic construct
Sample: MutSalpha on mismatched DNA in the presence of ADP
Deposition Authors: Bruekner SR
,
Liaci AM ,
Sixma TK
Sample: MutSalpha on mismatched DNA in the presence of ADP
Deposition Authors: Bruekner SR
,
Liaci AM ,
Sixma TK
Unexpected moves: a conformational change in MutS alpha enables high-affinity DNA mismatch binding.
Bruekner SR ,
Pieters W ,
Fish A,
Liaci AM ,
Scheffers S,
Rayner E ,
Kaldenbach D,
Drost L,
Dekker M,
van Hees-Stuivenberg S,
Delzenne-Goette E,
de Konink C,
Houlleberghs H,
Dubbink HJ ,
AlSaegh A,
de Wind N ,
Forster F ,
Te Riele H ,
Sixma TK
(2023) Nucleic Acids Res , 51 , 1173 - 1188
,
Pieters W ,
Fish A,
Liaci AM ,
Scheffers S,
Rayner E ,
Kaldenbach D,
Drost L,
Dekker M,
van Hees-Stuivenberg S,
Delzenne-Goette E,
de Konink C,
Houlleberghs H,
Dubbink HJ ,
AlSaegh A,
de Wind N ,
Forster F ,
Te Riele H ,
Sixma TK
(2023) Nucleic Acids Res , 51 , 1173 - 1188
Grant Support:
- Netherlands Organisation for Scientific Research (NWO): 714.016.002 (Netherlands)
- European Commission: H2020-MSCA-ITN-2016 722433 DNAREPAIRMAN (European Union)