EMD-15417

Single-particle
2.8 Å
EMD-15417
3D View Gallery
Deposition: 19/07/2022
Map released: 25/01/2023
Last modified: 24/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-15417
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8ag6 summary report (pdf.gz) Map and 8ag6 FULL report (pdf.gz)
EMICSS annotations (xml)

human MutSalpha (MSH2/MSH6) binding to DNA with a GT mismatch

EMD-15417

Single-particle
2.8 Å
EMD-15417
3D View Gallery
Deposition: 19/07/2022
Map released: 25/01/2023
Last modified: 24/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: MutSalpha on mismatched DNA
Fitted models: 8ag6

Deposition Authors: Bruekner SR, Sixma TK
Unexpected moves: a conformational change in MutS alpha enables high-affinity DNA mismatch binding.
Bruekner SR, Pieters W , Fish A, Liaci AM, Scheffers S, Rayner E , Kaldenbach D, Drost L, Dekker M, van Hees-Stuivenberg S, Delzenne-Goette E, de Konink C, Houlleberghs H, Dubbink HJ , AlSaegh A, de Wind N , Forster F , Te Riele H , Sixma TK
(2023) Nucleic Acids Res , 51 , 1173 - 1188
PUBMED: 36715327
DOI: doi:10.1093/nar/gkad015
ISSN: 1362-4962
ASTM: NARHAD