EMD-15234
Structure of self-assembling engineered protein nanocage (EPN) fused with hepatitis A pX protein
EMD-15234
Single-particle6.7 Å
Deposition: 23/06/2022Map released: 10/08/2022
Last modified: 06/11/2024
Sample Organism:
Homo sapiens,
Human immunodeficiency virus type 1 BH10
Sample: EPN-pX
Fitted models: 8a8n
Deposition Authors: Duyvesteyn HME, Stuart DI
Sample: EPN-pX
Fitted models: 8a8n
Deposition Authors: Duyvesteyn HME, Stuart DI
Nonlytic cellular release of hepatitis A virus requires dual capsid recruitment of the ESCRT-associated Bro1 domain proteins HD-PTP and ALIX.
Shirasaki T 
,
Feng H,
Duyvesteyn HME,
Fusco WG,
McKnight KL,
Xie L,
Boyce M ,
Kumar S,
Barouch-Bentov R,
Gonzalez-Lopez O,
McNamara R ,
Wang L,
Hertel-Wulff A,
Chen X,
Einav S ,
Duncan JA,
Kapustina M,
Fry EE,
Stuart DI,
Lemon SM
(2022) PLoS Pathog , 18 , e1010543 - e1010543
,
Feng H,
Duyvesteyn HME,
Fusco WG,
McKnight KL,
Xie L,
Boyce M ,
Kumar S,
Barouch-Bentov R,
Gonzalez-Lopez O,
McNamara R ,
Wang L,
Hertel-Wulff A,
Chen X,
Einav S ,
Duncan JA,
Kapustina M,
Fry EE,
Stuart DI,
Lemon SM
(2022) PLoS Pathog , 18 , e1010543 - e1010543
Grant Support:
- National Institutes of Health/National Cancer Institute (NIH/NCI): R01-AI103083 (United States)
- National Institutes of Health/National Cancer Institute (NIH/NCI): R01-AI131685 (United States)
- National Institutes of Health/National Cancer Institute (NIH/NCI): R01-AI088255 (United States)
- National Institutes of Health/National Cancer Institute (NIH/NCI): R01-AI150095 (United States)
- Wellcome Trust: ALR00750 (United Kingdom)
- Medical Research Council (MRC, United Kingdom): MR/N00065X/1 (United Kingdom)