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EMD-14811
SARS-CoV-2 S 2P trimer in complex with monovalent DARPin R2 (State 1) - Focused Refinement
EMD-14811
Single-particle6.1 Å
Deposition: 21/04/2022Map released: 04/05/2022
Last modified: 28/12/2022
Sample Organism:
Severe acute respiratory syndrome coronavirus 2,
synthetic construct
Sample: SARS-CoV-2 S 2P trimer in complex with monovalent DARPin R2
Deposition Authors: Hurdiss DL
,
Drulyte I
Sample: SARS-CoV-2 S 2P trimer in complex with monovalent DARPin R2
Deposition Authors: Hurdiss DL
,
Drulyte I
The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants.
Rothenberger S ,
Hurdiss DL ,
Walser M,
Malvezzi F,
Mayor J,
Ryter S ,
Moreno H,
Liechti N ,
Bosshart A,
Iss C ,
Calabro V,
Cornelius A,
Hospodarsch T,
Neculcea A,
Looser T,
Schlegel A,
Fontaine S,
Villemagne D ,
Paladino M,
Schiegg D,
Mangold S,
Reichen C,
Radom F,
Kaufmann Y,
Schaible D,
Schlegel I,
Zitt C,
Sigrist G,
Straumann M,
Wolter J,
Comby M,
Sacarcelik F,
Drulyte I ,
Lyoo H ,
Wang C,
Li W ,
Du W,
Binz HK ,
Herrup R,
Lusvarghi S ,
Neerukonda SN,
Vassell R,
Wang W,
Adler JM ,
Eschke K,
Nascimento M ,
Abdelgawad A,
Gruber AD,
Bushe J ,
Kershaw O,
Knutson CG,
Balavenkatraman KK,
Ramanathan K,
Wyler E ,
Teixeira Alves LG,
Lewis S,
Watson R,
Haeuptle MA,
Zurcher A,
Dawson KM ,
Steiner D,
Weiss CD ,
Amstutz P,
van Kuppeveld FJM,
Stumpp MT ,
Bosch BJ ,
Engler O ,
Trimpert J
(2022) Nat Biotechnol , 40 , 1845 - 1854
,
Hurdiss DL ,
Walser M,
Malvezzi F,
Mayor J,
Ryter S ,
Moreno H,
Liechti N ,
Bosshart A,
Iss C ,
Calabro V,
Cornelius A,
Hospodarsch T,
Neculcea A,
Looser T,
Schlegel A,
Fontaine S,
Villemagne D ,
Paladino M,
Schiegg D,
Mangold S,
Reichen C,
Radom F,
Kaufmann Y,
Schaible D,
Schlegel I,
Zitt C,
Sigrist G,
Straumann M,
Wolter J,
Comby M,
Sacarcelik F,
Drulyte I ,
Lyoo H ,
Wang C,
Li W ,
Du W,
Binz HK ,
Herrup R,
Lusvarghi S ,
Neerukonda SN,
Vassell R,
Wang W,
Adler JM ,
Eschke K,
Nascimento M ,
Abdelgawad A,
Gruber AD,
Bushe J ,
Kershaw O,
Knutson CG,
Balavenkatraman KK,
Ramanathan K,
Wyler E ,
Teixeira Alves LG,
Lewis S,
Watson R,
Haeuptle MA,
Zurcher A,
Dawson KM ,
Steiner D,
Weiss CD ,
Amstutz P,
van Kuppeveld FJM,
Stumpp MT ,
Bosch BJ ,
Engler O ,
Trimpert J
(2022) Nat Biotechnol , 40 , 1845 - 1854
Grant Support:
- Other private: (Switzerland)