EMD-14722

Single-particle
2.85 Å
EMD-14722
3D View Gallery
Deposition: 05/04/2022
Map released: 12/10/2022
Last modified: 13/12/2023
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-14722

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of USP1-UAF1 bound to FANCI and mono-ubiquitinated FANCD2 with ML323 (consensus reconstruction)

EMD-14722

Single-particle
2.85 Å
EMD-14722
3D View Gallery
Deposition: 05/04/2022
Map released: 12/10/2022
Last modified: 13/12/2023
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: USP1(C90S)-UAF1 bound to FANCI and mono-ubiquitinated FANCD2 with dsDNA and ML323

Deposition Authors: Rennie ML , Walden H
Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site.
Rennie ML , Arkinson C, Chaugule VK, Walden H
(2022) Sci Adv , 8 , eabq6353 - eabq6353
PUBMED: 36170365
DOI: doi:10.1126/sciadv.abq6353
ISSN: 2375-2548