EMD-12798

Single-particle
12.0 Å
EMD-12798
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Deposition: 22/04/2021
Map released: 19/01/2022
Last modified: 01/06/2022
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-12798
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Hexameric coxsackievirus B3 2C protein in complex with S-fluoxetine

EMD-12798

Single-particle
12.0 Å
EMD-12798
3D View Gallery
Deposition: 22/04/2021
Map released: 19/01/2022
Last modified: 01/06/2022
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Coxsackievirus B3 (strain Nancy)
Sample: Hexameric coxsackievirus B3 2C protein in complex with S-fluoxetine

Deposition Authors: Hurdiss DL , Forster F
Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex.
Hurdiss DL , El Kazzi P, Bauer L , Papageorgiou N, Ferron FP , Donselaar T, van Vliet ALW, Shamorkina TM , Snijder J , Canard B , Decroly E , Brancale A , Zeev-Ben-Mordehai T , Forster F , van Kuppeveld FJM , Coutard B
(2022) Sci Adv , 8 , eabj7615 - eabj7615
PUBMED: 34985963
DOI: doi:10.1126/sciadv.abj7615
ISSN: 2375-2548