EMD-12798
Hexameric coxsackievirus B3 2C protein in complex with S-fluoxetine
EMD-12798
Single-particle12.0 Å
Deposition: 22/04/2021Map released: 19/01/2022
Last modified: 01/06/2022
Sample Organism:
Coxsackievirus B3 (strain Nancy)
Sample: Hexameric coxsackievirus B3 2C protein in complex with S-fluoxetine
Deposition Authors: Hurdiss DL
,
Forster F
Sample: Hexameric coxsackievirus B3 2C protein in complex with S-fluoxetine
Deposition Authors: Hurdiss DL
,
Forster F
Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex.
Hurdiss DL ,
El Kazzi P,
Bauer L ,
Papageorgiou N,
Ferron FP ,
Donselaar T,
van Vliet ALW,
Shamorkina TM ,
Snijder J ,
Canard B ,
Decroly E ,
Brancale A ,
Zeev-Ben-Mordehai T ,
Forster F ,
van Kuppeveld FJM ,
Coutard B
(2022) Sci Adv , 8 , eabj7615 - eabj7615
,
El Kazzi P,
Bauer L ,
Papageorgiou N,
Ferron FP ,
Donselaar T,
van Vliet ALW,
Shamorkina TM ,
Snijder J ,
Canard B ,
Decroly E ,
Brancale A ,
Zeev-Ben-Mordehai T ,
Forster F ,
van Kuppeveld FJM ,
Coutard B
(2022) Sci Adv , 8 , eabj7615 - eabj7615
Grant Support:
- H2020 Marie Curie Actions of the European Commission: 842333 (Netherlands)
- Netherlands Organisation for Scientific Research (NWO): ECHO-711.017.002 (Netherlands)
- H2020 Marie Curie Actions of the European Commission: 642434 (Netherlands)
- Netherlands Organisation for Scientific Research (NWO): NWO-VICI-91812628 (Netherlands)
- European Research Council (ERC): 724425 (Netherlands)