EMD-12374

Tomography
EMD-12374
Gallery
Deposition: 16/02/2021
Map released: 05/05/2021
Last modified: 05/05/2021
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EMD-12374
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Tomogram of mutant huntingtin inclusion (recruitment foci) in the cytoplasm of hippocampal CA1 neuron in 6 month old zQ175 mice

EMD-12374

Tomography
EMD-12374
Gallery
Deposition: 16/02/2021
Map released: 05/05/2021
Last modified: 05/05/2021
Overview Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus
Sample: Mutant huntingtin containing organelle in hippocampal CA1 neuron from zQ175 knock-in mice.

Deposition Authors: Zhou Y, Saibil HR
Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington's disease.
Zhou Y, Peskett TR , Landles C , Warner JB, Sathasivam K, Smith EJ, Chen S, Wetzel R, Lashuel HA, Bates GP , Saibil HR
(2021) Acta Neuropathol Commun , 9 , 70 - 70
PUBMED: 33853668
DOI: doi:10.1186/s40478-021-01172-z
ISSN: 2051-5960
Grant Support: