EMDB EMD-12174

Single particle reconstruction
3.8Å resolution

The catalytic core lobe of human telomerase in complex with a telomeric DNA substrate

Map released:
Last modified:
Overview of EMD-12174
Source organisms:
Fitted atomic model: 7bg9
Primary publication:
Structure of human telomerase holoenzyme with bound telomeric DNA.
Ghanim GE, Fountain AJ, van Roon AM, Rangan R, Das R, Collins K, Nguyen THD
Nature - (2021)
PMID: 33883742

Function and Biology Details

Sample name: Human telomerase catalytic core in complex with a telomeric DNA substrate
Nucleic acids: DNA (5'-D(P*TP*TP*AP*GP*GP*G)-3'), RNA (256-MER)
Proteins: Human telomerase catalytic core in complex with a telomeric DNA substrate, Telomerase reverse transcriptase, Histone, DNA, Telomerase reverse transcriptase,Telomerase reverse transcriptase, Histone H2B, Histone H2A

Experimental Information Details

Resolution: 3.8Å
Resolution method: FSC 0.143 CUT-OFF
Reconstruction software: RELION
Microscope: FEI TITAN KRIOS
Detector: OTHER