EMDB EMD-11978

Single particle reconstruction
3.79Å resolution

Nanobody E bound to Spike-RBD in a localized reconstruction.

Map released:
Overview of EMD-11978
Fitted atomic model: 7b14
Primary publication:
Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape.
Koenig PA, Das H, Liu H, Kummerer BM, Gohr FN, Jenster LM, Schiffelers LDJ, Tesfamariam YM, Uchima M, Wuerth JD, Gatterdam K, Ruetalo N, Christensen MH, Fandrey CI, Normann S, Todtmann JMP, Pritzl S, Hanke L, Boos J, Yuan M, Zhu X, Schmid-Burgk JL, Kato H, Schindler M, Wilson IA, Geyer M, Ludwig KU, Hallberg BM, Wu NC, Schmidt FI
Science 371 - (2021)
PMID: 33436526

Function and Biology Details

Sample name: SARS-CoV-2 glycoprotein in complex with a nanobody named V
Ligand: 2-acetamido-2-deoxy-beta-D-glucopyranose
Proteins: SARS-CoV-2 glycoprotein in complex with a nanobody named V, Spike glycoprotein, Nanobody against SARS-CoV-2, Spike glycoprotein, Nanobody against SARS-CoV-2

Experimental Information Details

Resolution: 3.79Å
Resolution method: FSC 0.143 CUT-OFF
Reconstruction software: cryoSPARC
Microscope: FEI TITAN KRIOS
Detector: OTHER