EMDB EMD-11927

Single particle reconstruction
2.97Å resolution

Melanocortin receptor 4 (MC4R) Gs protein complex

Map released:
Overview of EMD-11927
Source organisms:
Fitted atomic model: 7aue
Primary publication:
Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling.
Israeli H, Degtjarik O, Fierro F, Chunilal V, Gill AK, Roth NJ, Botta J, Prabahar V, Peleg Y, Chan LF, Ben-Zvi D, McCormick PJ, Niv MY, Shalev-Benami M
Science - (2021)
PMID: 33858992

Function and Biology Details

Sample name: Melanocortine 4 (MC4R) - GalphaS protein comlex
Ligands: CALCIUM ION, water
Proteins: Melanocortine 4 (MC4R) - GalphaS protein comlex, Melanocortine 4 (MC4R) - GalphaS protein comlex, scFv16, AMINOSERINE, Melanocortin receptor 4, Guanine nucleotide-binding protein G(i) subunit alpha-1,Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, scFv16, AMINOSERINE

Experimental Information Details

Resolution: 2.97Å
Resolution method: FSC 0.143 CUT-OFF
Microscope: FEI TITAN KRIOS
Detector: OTHER