EMD-11777

Single-particle
26.0 Å
EMD-11777
3D View Gallery
Deposition: 22/09/2020
Map released: 13/01/2021
Last modified: 14/07/2021
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-11777

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

RET/GDF15/GFRAL extracellular complex negative stain envelope

EMD-11777

Single-particle
26.0 Å
EMD-11777
3D View Gallery
Deposition: 22/09/2020
Map released: 13/01/2021
Last modified: 14/07/2021
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Ternary complex of the human RET extracellular domain with the GDF15/GFRAL ligand-co-receptor pair

Deposition Authors: Adams SE, Earl CP, McDonald NQ
A two-site flexible clamp mechanism for RET-GDNF-GFR alpha 1 assembly reveals both conformational adaptation and strict geometric spacing.
Adams SE, Purkiss AG , Knowles PP, Nans A, Briggs DC , Borg A, Earl CP , Goodman KM, Nawrotek A, Borg AJ, McIntosh PB, Houghton FM , Kjaer S, McDonald NQ
(2021) Structure , 29 , 694 - 708.e7
PUBMED: 33484636
DOI: doi:10.1016/j.str.2020.12.012
ISSN: 0969-2126
ASTM: STRUE6
Grant Support: