EMDB EMD-10735

Single particle reconstruction
2.97Å resolution

Cryo-EM structure of trimeric human STEAP1 bound to three Fab120.545 fragments

Map released:
Last modified:
Overview of EMD-10735
Source organisms:
Fitted atomic model: 6y9b
Primary publication:
Cryo-EM structure and potential enzymatic function of human six-transmembrane epithelial antigen of the prostate 1.
Oosterheert W, Gros P
J.Biol.Chem. - (2020)
PMID: 32409586

Function and Biology Details

Sample name: Trimeric human six-transmembrane epithelial antigen of the prostate (STEAP1) bound to three Fab-fragments of antibody mAb120.545
Ligands: PROTOPORPHYRIN IX CONTAINING FE, 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHATE
Proteins: Trimeric human six-transmembrane epithelial antigen of the prostate (STEAP1) bound to three Fab-fragments of antibody mAb120.545, Fab-fragment 1 of antibody mAb120.545, Homo-trimeric STEAP1, chain a, b and c., Fab Fragment 2 of antibody mAb120.545, Fab-fragment 3 of antibody mAb120.545, Metalloreductase STEAP1, Fab120.545 light chain, Fab120.545 heavy chain

Experimental Information Details

Resolution: 2.97Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C3
Reconstruction software: RELION
Microscope: FEI TALOS ARCTICA
Detector: GATAN K2 SUMMIT (4k x 4k)