EMDB EMD-10576

Single particle reconstruction
2.6Å resolution

PKM2 in complex with L-threonine

Map released:
Overview of EMD-10576
Source organism: Homo sapiens [9606]
Fitted atomic model: 6tth
Related EM entries by publication: EMD-10563, EMD-10564, EMD-10574, EMD-10575, EMD-10577, EMD-10584
Primary publication:
Fragment-based drug discovery using cryo-EM.
Saur M, Hartshorn MJ, Dong J, Reeks J, Bunkoczi G, Jhoti H, Williams PA
Drug Discov Today - (2019)
PMID: 31877353

Function and Biology Details

Sample name: Pyruvate Kinase M2
Proteins: Pyruvate Kinase M2, Pyruvate kinase PKM

Experimental Information Details

Resolution: 2.6Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: D2
Reconstruction software: RELION
Microscope: OTHER
Detector: FEI FALCON III (4k x 4k)