EMD-0949
Cryo-EM structure of 90S small subunit preribosomes in transition states (State A)
EMD-0949
Single-particle3.2 Å
Deposition: 14/01/2020Map released: 16/09/2020
Last modified: 27/03/2024
Name: 90S pre-ribosome (Dhr1-depleted, state A)
Summary:
- Complex
- RNA
- Protein
- 40S ribosomal protein S1-A
- 40S ribosomal protein S4-A
- 40S ribosomal protein S5
- 40S ribosomal protein S6-A
- 40S ribosomal protein S7-A
- 40S ribosomal protein S8-A
- 40S ribosomal protein S9-A
- 40S ribosomal protein S11-A
- 40S ribosomal protein S12
- 40S ribosomal protein S13
- 40S ribosomal protein S14-A
- 40S ribosomal protein S16-A
- 40S ribosomal protein S18-A
- 40S ribosomal protein S22-B
- 40S ribosomal protein S23-A
- 40S ribosomal protein S24-A
- 40S ribosomal protein S27-A
- 40S ribosomal protein S28-A
- rRNA 2'-O-methyltransferase fibrillarin
- Nucleolar protein 56
- Nucleolar protein 58
- Ribosomal RNA-processing protein 9
- 13 kDa ribonucleoprotein-associated protein
- U3 small nucleolar RNA-associated protein 4
- U3 small nucleolar RNA-associated protein 5
- U3 small nucleolar RNA-associated protein 8
- U3 small nucleolar RNA-associated protein 9
- U3 small nucleolar RNA-associated protein 10
- U3 small nucleolar RNA-associated protein 15
- NET1-associated nuclear protein 1
- Periodic tryptophan protein 2
- U3 small nucleolar RNA-associated protein 12
- U3 small nucleolar RNA-associated protein 13
- U3 small nucleolar RNA-associated protein 18
- U3 small nucleolar RNA-associated protein 21
- U3 small nucleolar RNA-associated protein 6
- Bud site selection protein 21
- U3 small nucleolar RNA-associated protein 7
- U3 small nucleolar RNA-associated protein 11
- U3 small nucleolar RNA-associated protein MPP10
- U3 small nucleolar ribonucleoprotein protein IMP3
- U3 small nucleolar ribonucleoprotein protein IMP4
- Something about silencing protein 10
- Protein SOF1
- rRNA-processing protein FCF2
- rRNA-processing protein FCF1
- Ribosome biogenesis protein ENP2
- U3 small nucleolar ribonucleoprotein protein LCP5
- KRR1 small subunit processome component
- U3 small nucleolar RNA-associated protein 22
- Ribosomal RNA-processing protein 7
- Ribosomal RNA small subunit methyltransferase NEP1
- Ribosome biogenesis protein UTP30
- Ribosome biogenesis protein BMS1
- RNA 3'-terminal phosphate cyclase-like protein
- RNA cytidine acetyltransferase
- Nucleolar complex protein 14
- Nucleolar complex protein 4
- U3 small nucleolar RNA-associated protein 20
- U3 small nucleolar RNA-associated protein 14
- Essential nuclear protein 1
- Pno1
- Protein FAF1
- Regulator of rDNA transcription protein 14
- Protein BFR2
- Unassigned helices
- Ligand
Name: 90S pre-ribosome (Dhr1-depleted, state A)
Natural source [1]
Organism: Saccharomyces cerevisiae S288C
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 5 MDa | - |
Name: U3 snoRNA
Number of copies: 1
Number of copies: 1
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 106 kDa | - |
Name: 5' ETS
Number of copies: 1
Number of copies: 1
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 225 kDa | - |
Name: 18S pre-rRNA
Number of copies: 1
Number of copies: 1
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 582 kDa | - |
Name: 40S ribosomal protein S1-A
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [6]
Biological process:
cytoplasmic translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
structural constituent of ribosome
Cellular location:
cytosol cytosolic small ribosomal subunit 90S preribosome
cytoplasmic translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
structural constituent of ribosome
Cellular location:
cytosol cytosolic small ribosomal subunit 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 28 kDa | - |
Name: 40S ribosomal protein S4-A
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Biological process:
cytoplasmic translation translation
Molecular function:
RNA binding structural constituent of ribosome
Cellular location:
cytosol cytoplasm cytosolic small ribosomal subunit 90S preribosome
cytoplasmic translation translation
Molecular function:
RNA binding structural constituent of ribosome
Cellular location:
cytosol cytoplasm cytosolic small ribosomal subunit 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 29 kDa | - |
Name: 40S ribosomal protein S5
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [13]
Biological process:
regulation of translational fidelity translation maturation of SSU-rRNA cytoplasmic translation ribosomal subunit export from nucleus
Molecular function:
structural constituent of ribosome rRNA binding mRNA binding
Cellular location:
cytosolic small ribosomal subunit cytosol ribosome cytoplasm 90S preribosome
regulation of translational fidelity translation maturation of SSU-rRNA cytoplasmic translation ribosomal subunit export from nucleus
Molecular function:
structural constituent of ribosome rRNA binding mRNA binding
Cellular location:
cytosolic small ribosomal subunit cytosol ribosome cytoplasm 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 25 kDa | - |
Name: 40S ribosomal protein S6-A
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Biological process:
translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
structural constituent of ribosome
Cellular location:
cytosolic small ribosomal subunit small-subunit processome 90S preribosome nucleoplasm cytosol
translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
structural constituent of ribosome
Cellular location:
cytosolic small ribosomal subunit small-subunit processome 90S preribosome nucleoplasm cytosol
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 27 kDa | - |
Name: 40S ribosomal protein S7-A
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [10]
Biological process:
rRNA processing ribosomal small subunit biogenesis ribosome biogenesis cytoplasmic translation
Molecular function:
structural constituent of ribosome
Cellular location:
small-subunit processome 90S preribosome cytosolic small ribosomal subunit nucleoplasm cytosol
rRNA processing ribosomal small subunit biogenesis ribosome biogenesis cytoplasmic translation
Molecular function:
structural constituent of ribosome
Cellular location:
small-subunit processome 90S preribosome cytosolic small ribosomal subunit nucleoplasm cytosol
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 21 kDa | - |
Name: 40S ribosomal protein S8-A
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [6]
Biological process:
translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
structural constituent of ribosome
Cellular location:
cytosolic small ribosomal subunit cytosol 90S preribosome
translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
structural constituent of ribosome
Cellular location:
cytosolic small ribosomal subunit cytosol 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 22 kDa | - |
Name: 40S ribosomal protein S9-A
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
translation ribosomal small subunit biogenesis maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
structural constituent of ribosome rRNA binding
Cellular location:
cytosolic small ribosomal subunit 90S preribosome small-subunit processome nucleoplasm cytosol cytoplasm
translation ribosomal small subunit biogenesis maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
structural constituent of ribosome rRNA binding
Cellular location:
cytosolic small ribosomal subunit 90S preribosome small-subunit processome nucleoplasm cytosol cytoplasm
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 22 kDa | - |
Name: 40S ribosomal protein S11-A
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [7]
Biological process:
translation ribosomal small subunit assembly maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
structural constituent of ribosome
Cellular location:
90S preribosome cytosolic small ribosomal subunit cytosol
translation ribosomal small subunit assembly maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
structural constituent of ribosome
Cellular location:
90S preribosome cytosolic small ribosomal subunit cytosol
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 17 kDa | - |
Name: 40S ribosomal protein S12
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [9]
Biological process:
ribosomal small subunit assembly ribosomal small subunit biogenesis maturation of SSU-rRNA maintenance of translational fidelity cytoplasmic translation
Molecular function:
structural constituent of ribosome
Cellular location:
cytoplasm cytosolic small ribosomal subunit cytosol
ribosomal small subunit assembly ribosomal small subunit biogenesis maturation of SSU-rRNA maintenance of translational fidelity cytoplasmic translation
Molecular function:
structural constituent of ribosome
Cellular location:
cytoplasm cytosolic small ribosomal subunit cytosol
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 15 kDa | - |
Name: 40S ribosomal protein S13
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Biological process:
cytoplasmic translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
structural constituent of ribosome small ribosomal subunit rRNA binding
Cellular location:
cytoplasm cytosolic small ribosomal subunit cytosol 90S preribosome
cytoplasmic translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
structural constituent of ribosome small ribosomal subunit rRNA binding
Cellular location:
cytoplasm cytosolic small ribosomal subunit cytosol 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 17 kDa | - |
Name: 40S ribosomal protein S14-A
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
ribosomal small subunit assembly cytoplasmic translation translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
structural constituent of ribosome mRNA binding
Cellular location:
nucleoplasm 90S preribosome cytosol small-subunit processome cytosolic small ribosomal subunit
ribosomal small subunit assembly cytoplasmic translation translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
structural constituent of ribosome mRNA binding
Cellular location:
nucleoplasm 90S preribosome cytosol small-subunit processome cytosolic small ribosomal subunit
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 14 kDa | - |
Name: 40S ribosomal protein S16-A
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [7]
Biological process:
translational initiation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
RNA binding structural constituent of ribosome
Cellular location:
cytosol cytosolic small ribosomal subunit 90S preribosome
translational initiation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
RNA binding structural constituent of ribosome
Cellular location:
cytosol cytosolic small ribosomal subunit 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 15 kDa | - |
Name: 40S ribosomal protein S18-A
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [9]
Biological process:
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal subunit export from nucleus cytoplasmic translation
Molecular function:
structural constituent of ribosome
Cellular location:
small ribosomal subunit mitochondrion cytoplasm cytosolic small ribosomal subunit cytosol
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal subunit export from nucleus cytoplasmic translation
Molecular function:
structural constituent of ribosome
Cellular location:
small ribosomal subunit mitochondrion cytoplasm cytosolic small ribosomal subunit cytosol
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 17 kDa | - |
Name: 40S ribosomal protein S22-B
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [4]
Biological process:
cytoplasmic translation
Molecular function:
structural constituent of ribosome
Cellular location:
cytosolic small ribosomal subunit cytosol
cytoplasmic translation
Molecular function:
structural constituent of ribosome
Cellular location:
cytosolic small ribosomal subunit cytosol
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 14 kDa | - |
Name: 40S ribosomal protein S23-A
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Biological process:
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maintenance of translational fidelity regulation of translational fidelity translation
Molecular function:
structural constituent of ribosome
Cellular location:
cytosol ribosome cytosolic small ribosomal subunit
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maintenance of translational fidelity regulation of translational fidelity translation
Molecular function:
structural constituent of ribosome
Cellular location:
cytosol ribosome cytosolic small ribosomal subunit
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 16 kDa | - |
Name: 40S ribosomal protein S24-A
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [6]
Biological process:
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cytoplasmic translation
Molecular function:
structural constituent of ribosome
Cellular location:
mitochondrion cytosol cytosolic small ribosomal subunit
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cytoplasmic translation
Molecular function:
structural constituent of ribosome
Cellular location:
mitochondrion cytosol cytosolic small ribosomal subunit
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 15 kDa | - |
Name: 40S ribosomal protein S27-A
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Biological process:
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) translation ribosomal small subunit assembly
Molecular function:
zinc ion binding structural constituent of ribosome
Cellular location:
cytosolic small ribosomal subunit cytoplasm cytosol
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) translation ribosomal small subunit assembly
Molecular function:
zinc ion binding structural constituent of ribosome
Cellular location:
cytosolic small ribosomal subunit cytoplasm cytosol
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 8 kDa | - |
Name: 40S ribosomal protein S28-A
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Biological process:
maturation of SSU-rRNA translation positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ribosomal small subunit assembly ribosomal subunit export from nucleus
Molecular function:
structural constituent of ribosome
Cellular location:
cytosol cytosolic small ribosomal subunit
maturation of SSU-rRNA translation positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ribosomal small subunit assembly ribosomal subunit export from nucleus
Molecular function:
structural constituent of ribosome
Cellular location:
cytosol cytosolic small ribosomal subunit
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 7 kDa | - |
Name: rRNA 2'-O-methyltransferase fibrillarin
EC number: 2.1.1.-
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
EC number: 2.1.1.-
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [16]
Biological process:
box C/D sno(s)RNA 3'-end processing snoRNA guided rRNA 2'-O-methylation regulation of transcription by RNA polymerase I rRNA 2'-O-methylation maturation of SSU-rRNA rRNA processing rRNA methylation
Molecular function:
histone H2AQ104 methyltransferase activity rRNA methyltransferase activity RNA binding O-methyltransferase activity
Cellular location:
small-subunit processome nucleoplasm nucleolus 90S preribosome box C/D methylation guide snoRNP complex
box C/D sno(s)RNA 3'-end processing snoRNA guided rRNA 2'-O-methylation regulation of transcription by RNA polymerase I rRNA 2'-O-methylation maturation of SSU-rRNA rRNA processing rRNA methylation
Molecular function:
histone H2AQ104 methyltransferase activity rRNA methyltransferase activity RNA binding O-methyltransferase activity
Cellular location:
small-subunit processome nucleoplasm nucleolus 90S preribosome box C/D methylation guide snoRNP complex
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 34 kDa | - |
Name: Nucleolar protein 56
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [13]
Biological process:
box C/D sno(s)RNA 3'-end processing rRNA processing maturation of SSU-rRNA snoRNA guided rRNA 2'-O-methylation rRNA modification
Molecular function:
snoRNA binding mRNA binding
Cellular location:
small-subunit processome nucleolus box C/D methylation guide snoRNP complex 90S preribosome nucleoplasm nucleus
box C/D sno(s)RNA 3'-end processing rRNA processing maturation of SSU-rRNA snoRNA guided rRNA 2'-O-methylation rRNA modification
Molecular function:
snoRNA binding mRNA binding
Cellular location:
small-subunit processome nucleolus box C/D methylation guide snoRNP complex 90S preribosome nucleoplasm nucleus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 56 kDa | - |
Name: Nucleolar protein 58
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [16]
Biological process:
rRNA processing endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) box C/D sno(s)RNA 3'-end processing endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) snoRNA guided rRNA 2'-O-methylation protein localization to nucleolus maturation of SSU-rRNA endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
snoRNA binding mRNA binding snRNA binding
Cellular location:
90S preribosome small-subunit processome nucleolus nucleoplasm box C/D methylation guide snoRNP complex
rRNA processing endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) box C/D sno(s)RNA 3'-end processing endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) snoRNA guided rRNA 2'-O-methylation protein localization to nucleolus maturation of SSU-rRNA endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
snoRNA binding mRNA binding snRNA binding
Cellular location:
90S preribosome small-subunit processome nucleolus nucleoplasm box C/D methylation guide snoRNP complex
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 57 kDa | - |
Name: Ribosomal RNA-processing protein 9
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
maturation of SSU-rRNA endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
snoRNA binding U3 snoRNA binding
Cellular location:
small-subunit processome nucleoplasm box C/D methylation guide snoRNP complex nucleolus 90S preribosome
maturation of SSU-rRNA endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
snoRNA binding U3 snoRNA binding
Cellular location:
small-subunit processome nucleoplasm box C/D methylation guide snoRNP complex nucleolus 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 65 kDa | - |
Name: 13 kDa ribonucleoprotein-associated protein
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [16]
Biological process:
box C/D sno(s)RNA 3'-end processing mRNA splicing, via spliceosome maturation of SSU-rRNA snoRNA guided rRNA 2'-O-methylation spliceosomal complex assembly maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
U3 snoRNA binding U4 snRNA binding RNA binding
Cellular location:
small-subunit processome nucleoplasm nucleus box C/D methylation guide snoRNP complex U4/U6 x U5 tri-snRNP complex precatalytic spliceosome nucleolus
box C/D sno(s)RNA 3'-end processing mRNA splicing, via spliceosome maturation of SSU-rRNA snoRNA guided rRNA 2'-O-methylation spliceosomal complex assembly maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
U3 snoRNA binding U4 snRNA binding RNA binding
Cellular location:
small-subunit processome nucleoplasm nucleus box C/D methylation guide snoRNP complex U4/U6 x U5 tri-snRNP complex precatalytic spliceosome nucleolus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 13 kDa | - |
Name: U3 small nucleolar RNA-associated protein 4
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 87 kDa | - |
Name: U3 small nucleolar RNA-associated protein 5
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 72 kDa | - |
Name: U3 small nucleolar RNA-associated protein 8
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA positive regulation of transcription by RNA polymerase I tRNA export from nucleus
Molecular function:
U3 snoRNA binding tRNA binding
Cellular location:
t-UTP complex small-subunit processome nucleolus rDNA heterochromatin 90S preribosome
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA positive regulation of transcription by RNA polymerase I tRNA export from nucleus
Molecular function:
U3 snoRNA binding tRNA binding
Cellular location:
t-UTP complex small-subunit processome nucleolus rDNA heterochromatin 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 80 kDa | - |
Name: U3 small nucleolar RNA-associated protein 9
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [12]
Biological process:
maturation of SSU-rRNA maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) positive regulation of transcription by RNA polymerase I tRNA re-export from nucleus
Molecular function:
tRNA binding U3 snoRNA binding
Cellular location:
rDNA heterochromatin nucleus 90S preribosome t-UTP complex small-subunit processome nucleolus
maturation of SSU-rRNA maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) positive regulation of transcription by RNA polymerase I tRNA re-export from nucleus
Molecular function:
tRNA binding U3 snoRNA binding
Cellular location:
rDNA heterochromatin nucleus 90S preribosome t-UTP complex small-subunit processome nucleolus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 65 kDa | - |
Name: U3 small nucleolar RNA-associated protein 10
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [16]
Biological process:
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) positive regulation of transcription by RNA polymerase I endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
snoRNA binding U3 snoRNA binding
Cellular location:
mitochondrion nucleolus rDNA heterochromatin small-subunit processome preribosome, small subunit precursor nucleoplasm t-UTP complex 90S preribosome
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) positive regulation of transcription by RNA polymerase I endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
snoRNA binding U3 snoRNA binding
Cellular location:
mitochondrion nucleolus rDNA heterochromatin small-subunit processome preribosome, small subunit precursor nucleoplasm t-UTP complex 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 200 kDa | - |
Name: U3 small nucleolar RNA-associated protein 15
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
maturation of SSU-rRNA positive regulation of transcription by RNA polymerase I maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA processing
Molecular function:
U3 snoRNA binding
Cellular location:
nucleoplasm 90S preribosome rDNA heterochromatin small-subunit processome t-UTP complex nucleolus
maturation of SSU-rRNA positive regulation of transcription by RNA polymerase I maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA processing
Molecular function:
U3 snoRNA binding
Cellular location:
nucleoplasm 90S preribosome rDNA heterochromatin small-subunit processome t-UTP complex nucleolus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 57 kDa | - |
Name: NET1-associated nuclear protein 1
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [14]
Biological process:
positive regulation of rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA positive regulation of transcription by RNA polymerase I
Molecular function:
RNA binding mRNA binding U3 snoRNA binding
Cellular location:
small-subunit processome nucleolus peroxisome nucleoplasm t-UTP complex rDNA heterochromatin 90S preribosome
positive regulation of rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA positive regulation of transcription by RNA polymerase I
Molecular function:
RNA binding mRNA binding U3 snoRNA binding
Cellular location:
small-subunit processome nucleolus peroxisome nucleoplasm t-UTP complex rDNA heterochromatin 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 101 kDa | - |
Name: Periodic tryptophan protein 2
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [15]
Biological process:
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) establishment of cell polarity endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit assembly septum digestion after cytokinesis endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
mRNA binding
Cellular location:
nucleoplasm Pwp2p-containing subcomplex of 90S preribosome 90S preribosome nucleolus cytoplasm small-subunit processome
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) establishment of cell polarity endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit assembly septum digestion after cytokinesis endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
mRNA binding
Cellular location:
nucleoplasm Pwp2p-containing subcomplex of 90S preribosome 90S preribosome nucleolus cytoplasm small-subunit processome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 104 kDa | - |
Name: U3 small nucleolar RNA-associated protein 12
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [12]
Biological process:
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA
Molecular function:
snoRNA binding U3 snoRNA binding
Cellular location:
small-subunit processome nucleoplasm Pwp2p-containing subcomplex of 90S preribosome 90S preribosome nucleolus
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA
Molecular function:
snoRNA binding U3 snoRNA binding
Cellular location:
small-subunit processome nucleoplasm Pwp2p-containing subcomplex of 90S preribosome 90S preribosome nucleolus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 106 kDa | - |
Name: U3 small nucleolar RNA-associated protein 13
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA
Molecular function:
U3 snoRNA binding
Cellular location:
90S preribosome small-subunit processome nucleolus Pwp2p-containing subcomplex of 90S preribosome nucleoplasm
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA
Molecular function:
U3 snoRNA binding
Cellular location:
90S preribosome small-subunit processome nucleolus Pwp2p-containing subcomplex of 90S preribosome nucleoplasm
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 91 kDa | - |
Name: U3 small nucleolar RNA-associated protein 18
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [10]
Biological process:
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA fragment catabolic process maturation of SSU-rRNA
Cellular location:
Pwp2p-containing subcomplex of 90S preribosome nucleolus 90S preribosome small-subunit processome nucleoplasm
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA fragment catabolic process maturation of SSU-rRNA
Cellular location:
Pwp2p-containing subcomplex of 90S preribosome nucleolus 90S preribosome small-subunit processome nucleoplasm
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 66 kDa | - |
Name: U3 small nucleolar RNA-associated protein 21
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Biological process:
maturation of SSU-rRNA rRNA processing
Cellular location:
nucleus nucleolus 90S preribosome Pwp2p-containing subcomplex of 90S preribosome nucleoplasm small-subunit processome
maturation of SSU-rRNA rRNA processing
Cellular location:
nucleus nucleolus 90S preribosome Pwp2p-containing subcomplex of 90S preribosome nucleoplasm small-subunit processome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 104 kDa | - |
Name: U3 small nucleolar RNA-associated protein 6
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [13]
Biological process:
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
identical protein binding snoRNA binding U3 snoRNA binding
Cellular location:
small-subunit processome nucleolus nucleoplasm Pwp2p-containing subcomplex of 90S preribosome 90S preribosome
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
identical protein binding snoRNA binding U3 snoRNA binding
Cellular location:
small-subunit processome nucleolus nucleoplasm Pwp2p-containing subcomplex of 90S preribosome 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 52 kDa | - |
Name: Bud site selection protein 21
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Biological process:
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
U3 snoRNA binding
Cellular location:
90S preribosome nucleolus small-subunit processome
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
U3 snoRNA binding
Cellular location:
90S preribosome nucleolus small-subunit processome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 24 kDa | - |
Name: U3 small nucleolar RNA-associated protein 7
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [10]
Biological process:
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
nucleoplasm small-subunit processome nucleolus 90S preribosome preribosome, small subunit precursor
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
nucleoplasm small-subunit processome nucleolus 90S preribosome preribosome, small subunit precursor
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 62 kDa | - |
Name: U3 small nucleolar RNA-associated protein 11
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [10]
Biological process:
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA rRNA processing endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) translation
Cellular location:
small-subunit processome nucleoplasm nucleolus sno(s)RNA-containing ribonucleoprotein complex
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA rRNA processing endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) translation
Cellular location:
small-subunit processome nucleoplasm nucleolus sno(s)RNA-containing ribonucleoprotein complex
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 29 kDa | - |
Name: U3 small nucleolar RNA-associated protein MPP10
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [12]
Biological process:
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA
Molecular function:
identical protein binding
Cellular location:
Mpp10 complex sno(s)RNA-containing ribonucleoprotein complex nucleolus nucleoplasm nucleus small-subunit processome 90S preribosome
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA
Molecular function:
identical protein binding
Cellular location:
Mpp10 complex sno(s)RNA-containing ribonucleoprotein complex nucleolus nucleoplasm nucleus small-subunit processome 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 67 kDa | - |
Name: U3 small nucleolar ribonucleoprotein protein IMP3
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
rRNA processing maturation of SSU-rRNA ribosomal small subunit biogenesis
Molecular function:
rRNA binding RNA folding chaperone snoRNA binding
Cellular location:
nucleoplasm nucleolus small-subunit processome 90S preribosome Mpp10 complex
rRNA processing maturation of SSU-rRNA ribosomal small subunit biogenesis
Molecular function:
rRNA binding RNA folding chaperone snoRNA binding
Cellular location:
nucleoplasm nucleolus small-subunit processome 90S preribosome Mpp10 complex
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 21 kDa | - |
Name: U3 small nucleolar ribonucleoprotein protein IMP4
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [12]
Biological process:
maturation of SSU-rRNA rRNA processing ribosomal small subunit biogenesis
Molecular function:
RNA folding chaperone snoRNA binding rRNA primary transcript binding single-stranded telomeric DNA binding
Cellular location:
nucleolus small-subunit processome 90S preribosome nucleoplasm Mpp10 complex
maturation of SSU-rRNA rRNA processing ribosomal small subunit biogenesis
Molecular function:
RNA folding chaperone snoRNA binding rRNA primary transcript binding single-stranded telomeric DNA binding
Cellular location:
nucleolus small-subunit processome 90S preribosome nucleoplasm Mpp10 complex
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 33 kDa | - |
Name: Something about silencing protein 10
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [10]
Biological process:
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA
Molecular function:
identical protein binding
Cellular location:
small-subunit processome nucleus nucleolus nucleoplasm
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA
Molecular function:
identical protein binding
Cellular location:
small-subunit processome nucleus nucleolus nucleoplasm
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 70 kDa | - |
Name: Protein SOF1
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [7]
Biological process:
maturation of SSU-rRNA maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
mRNA binding
Cellular location:
nucleolus 90S preribosome small-subunit processome nucleoplasm
maturation of SSU-rRNA maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
mRNA binding
Cellular location:
nucleolus 90S preribosome small-subunit processome nucleoplasm
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 56 kDa | - |
Name: rRNA-processing protein FCF2
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [6]
Biological process:
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA processing endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
nucleolus nucleus
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA processing endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
nucleolus nucleus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 25 kDa | - |
Name: rRNA-processing protein FCF1
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Biological process:
maturation of SSU-rRNA endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
RNA endonuclease activity
Cellular location:
nucleoplasm small-subunit processome nucleolus
maturation of SSU-rRNA endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
RNA endonuclease activity
Cellular location:
nucleoplasm small-subunit processome nucleolus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 21 kDa | - |
Name: Ribosome biogenesis protein ENP2
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [5]
Biological process:
ribosomal small subunit biogenesis maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
nucleolus small-subunit processome 90S preribosome
ribosomal small subunit biogenesis maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
nucleolus small-subunit processome 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 81 kDa | - |
Name: U3 small nucleolar ribonucleoprotein protein LCP5
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Biological process:
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
small nuclear ribonucleoprotein complex sno(s)RNA-containing ribonucleoprotein complex small-subunit processome nucleolus
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
small nuclear ribonucleoprotein complex sno(s)RNA-containing ribonucleoprotein complex small-subunit processome nucleolus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 40 kDa | - |
Name: KRR1 small subunit processome component
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [10]
Biological process:
ribosomal small subunit biogenesis rRNA processing endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA
Molecular function:
RNA binding
Cellular location:
preribosome, small subunit precursor nucleolus small-subunit processome 90S preribosome nucleoplasm
ribosomal small subunit biogenesis rRNA processing endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA
Molecular function:
RNA binding
Cellular location:
preribosome, small subunit precursor nucleolus small-subunit processome 90S preribosome nucleoplasm
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 37 kDa | - |
Name: U3 small nucleolar RNA-associated protein 22
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [13]
Biological process:
regulation of ribosomal protein gene transcription by RNA polymerase II rRNA processing nucleolar large rRNA transcription by RNA polymerase I ribosomal small subunit assembly maturation of SSU-rRNA tRNA export from nucleus
Cellular location:
nucleoplasm CURI complex small-subunit processome nucleolus UTP-C complex nucleus 90S preribosome
regulation of ribosomal protein gene transcription by RNA polymerase II rRNA processing nucleolar large rRNA transcription by RNA polymerase I ribosomal small subunit assembly maturation of SSU-rRNA tRNA export from nucleus
Cellular location:
nucleoplasm CURI complex small-subunit processome nucleolus UTP-C complex nucleus 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 140 kDa | - |
Name: Ribosomal RNA-processing protein 7
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
ribosomal small subunit assembly rRNA processing nucleolar large rRNA transcription by RNA polymerase I regulation of ribosomal protein gene transcription by RNA polymerase II maturation of SSU-rRNA
Molecular function:
rRNA binding
Cellular location:
nucleoplasm CURI complex UTP-C complex nucleolus nucleus
ribosomal small subunit assembly rRNA processing nucleolar large rRNA transcription by RNA polymerase I regulation of ribosomal protein gene transcription by RNA polymerase II maturation of SSU-rRNA
Molecular function:
rRNA binding
Cellular location:
nucleoplasm CURI complex UTP-C complex nucleolus nucleus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 34 kDa | - |
Name: Ribosomal RNA small subunit methyltransferase NEP1
EC number: 2.1.1.260
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
EC number: 2.1.1.260
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [19]
Biological process:
ribosomal small subunit biogenesis rRNA base methylation endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA methylation endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA rRNA processing
Molecular function:
rRNA (pseudouridine) methyltransferase activity identical protein binding rRNA binding
Cellular location:
nucleoplasm cytoplasm 90S preribosome nucleolus nuclear microtubule nuclear periphery nucleus small-subunit processome
ribosomal small subunit biogenesis rRNA base methylation endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA methylation endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA rRNA processing
Molecular function:
rRNA (pseudouridine) methyltransferase activity identical protein binding rRNA binding
Cellular location:
nucleoplasm cytoplasm 90S preribosome nucleolus nuclear microtubule nuclear periphery nucleus small-subunit processome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 27 kDa | - |
Name: Ribosome biogenesis protein UTP30
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [7]
Biological process:
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA ribosomal small subunit biogenesis
Molecular function:
RNA binding
Cellular location:
nucleus nucleolus 90S preribosome
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA ribosomal small subunit biogenesis
Molecular function:
RNA binding
Cellular location:
nucleus nucleolus 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 31 kDa | - |
Name: Ribosome biogenesis protein BMS1
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [20]
Biological process:
maturation of SSU-rRNA ribosomal small subunit biogenesis endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) regulation of rRNA processing endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
U3 snoRNA binding ATP binding ATP hydrolysis activity GTPase activity GTP binding mRNA binding
Cellular location:
small-subunit processome mitochondrion nucleolus 90S preribosome nucleoplasm cytoplasm nucleus
maturation of SSU-rRNA ribosomal small subunit biogenesis endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) regulation of rRNA processing endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
U3 snoRNA binding ATP binding ATP hydrolysis activity GTPase activity GTP binding mRNA binding
Cellular location:
small-subunit processome mitochondrion nucleolus 90S preribosome nucleoplasm cytoplasm nucleus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 135 kDa | - |
Name: RNA 3'-terminal phosphate cyclase-like protein
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [13]
Biological process:
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA ribosomal small subunit biogenesis endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) regulation of rRNA processing rRNA processing endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
enzyme activator activity RNA endonuclease activity
Cellular location:
nucleolus small-subunit processome 90S preribosome nucleoplasm
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA ribosomal small subunit biogenesis endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) regulation of rRNA processing rRNA processing endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
enzyme activator activity RNA endonuclease activity
Cellular location:
nucleolus small-subunit processome 90S preribosome nucleoplasm
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 40 kDa | - |
Name: RNA cytidine acetyltransferase
EC number: 2.3.1.-
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
EC number: 2.3.1.-
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [15]
Biological process:
rRNA acetylation involved in maturation of SSU-rRNA maturation of SSU-rRNA tRNA wobble cytosine modification tRNA acetylation ribosomal small subunit biogenesis mRNA modification
Molecular function:
18S rRNA cytidine N-acetyltransferase activity ATP binding snoRNA binding tRNA binding tRNA cytidine N4-acetyltransferase activity
Cellular location:
preribosome, small subunit precursor nucleolus small-subunit processome 90S preribosome
rRNA acetylation involved in maturation of SSU-rRNA maturation of SSU-rRNA tRNA wobble cytosine modification tRNA acetylation ribosomal small subunit biogenesis mRNA modification
Molecular function:
18S rRNA cytidine N-acetyltransferase activity ATP binding snoRNA binding tRNA binding tRNA cytidine N4-acetyltransferase activity
Cellular location:
preribosome, small subunit precursor nucleolus small-subunit processome 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 119 kDa | - |
Name: Nucleolar complex protein 14
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [17]
Biological process:
ribosomal small subunit assembly endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit biogenesis endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
U3 snoRNA binding
Cellular location:
nucleoplasm nucleolus 90S preribosome small-subunit processome nucleus Noc4p-Nop14p complex mitochondrion preribosome, small subunit precursor
ribosomal small subunit assembly endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit biogenesis endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
U3 snoRNA binding
Cellular location:
nucleoplasm nucleolus 90S preribosome small-subunit processome nucleus Noc4p-Nop14p complex mitochondrion preribosome, small subunit precursor
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 94 kDa | - |
Name: Nucleolar complex protein 4
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [15]
Biological process:
maturation of SSU-rRNA endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit biogenesis endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA processing ribosomal small subunit assembly
Cellular location:
preribosome, small subunit precursor nucleolus small-subunit processome Noc4p-Nop14p complex cytosol nucleoplasm nucleus 90S preribosome
maturation of SSU-rRNA endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit biogenesis endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA processing ribosomal small subunit assembly
Cellular location:
preribosome, small subunit precursor nucleolus small-subunit processome Noc4p-Nop14p complex cytosol nucleoplasm nucleus 90S preribosome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 63 kDa | - |
Name: U3 small nucleolar RNA-associated protein 20
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [11]
Biological process:
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
mRNA binding
Cellular location:
cytoplasm preribosome, small subunit precursor 90S preribosome nucleolus nucleoplasm small-subunit processome
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular function:
mRNA binding
Cellular location:
cytoplasm preribosome, small subunit precursor 90S preribosome nucleolus nucleoplasm small-subunit processome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 287 kDa | - |
Name: U3 small nucleolar RNA-associated protein 14
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [8]
Biological process:
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA
Molecular function:
enzyme activator activity
Cellular location:
nucleolus small-subunit processome nucleoplasm
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of SSU-rRNA
Molecular function:
enzyme activator activity
Cellular location:
nucleolus small-subunit processome nucleoplasm
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 103 kDa | - |
Name: Essential nuclear protein 1
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [10]
Biological process:
rRNA processing endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) poly(A)+ mRNA export from nucleus maturation of SSU-rRNA
Molecular function:
snoRNA binding
Cellular location:
cytoplasm nucleus nucleolus 90S preribosome preribosome, small subunit precursor
rRNA processing endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) poly(A)+ mRNA export from nucleus maturation of SSU-rRNA
Molecular function:
snoRNA binding
Cellular location:
cytoplasm nucleus nucleolus 90S preribosome preribosome, small subunit precursor
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 55 kDa | - |
Name: Pno1
Number of copies: 1
Number of copies: 1
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 36 kDa | - |
Name: Protein FAF1
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [4]
Biological process:
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
nucleus cytoplasm nucleolus
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
nucleus cytoplasm nucleolus
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 38 kDa | - |
Name: Regulator of rDNA transcription protein 14
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [1]
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 23 kDa | - |
Name: Protein BFR2
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [5]
Biological process:
rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
nucleolus 90S preribosome small-subunit processome
rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular location:
nucleolus 90S preribosome small-subunit processome
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 61 kDa | - |
Name: Unassigned helices
Number of copies: 1
Number of copies: 1
Natural source
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 29 kDa | - |
Name: ZINC ION
HET code: ZN
Number of copies: 2
ChEMBL ChEBI DrugBank
HET code: ZN
Number of copies: 2
ChEMBL ChEBI DrugBank
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 65 Da | - |
Name: GUANOSINE-5'-TRIPHOSPHATE
HET code: GTP
Number of copies: 1
ChEMBL ChEBI DrugBank
HET code: GTP
Number of copies: 1
ChEMBL ChEBI DrugBank
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 523 Da | - |
Name: MAGNESIUM ION
HET code: MG
Number of copies: 1
ChEBI DrugBank
HET code: MG
Number of copies: 1
ChEBI DrugBank
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 24 Da | - |