EMDB EMD-0694

Single particle reconstruction
4.1Å resolution

Cryo-EM structure of human MLL1-NCP complex, binding mode1

Map released:
Last modified:
Overview of EMD-0694
Source organisms:
Fitted atomic model: 6kix
Related EM entries by publication: EMD-0693, EMD-0695, EMD-9998, EMD-9999
Primary publication:
Structural basis of nucleosome recognition and modification by MLL methyltransferases.
Xue H, Yao T, Cao M, Zhu G, Li Y, Yuan G, Chen Y, Lei M, Huang J
Nature - (2019)
PMID: 31485071

Function and Biology Details

Sample name: Human MLL1 complex associated with an unmodified nucleosome, binding mode 1
Ligands: S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION, LYSINE, GLUTAMINE
Nucleic acids: DNA (145-MER), DNA (145-MER)
Proteins: Human MLL1 complex associated with an unmodified nucleosome, binding mode 1, Human MLL1 complex, unmodified nucleosome, Histone H3, Histone H4, Histone H2A, Histone H2B 1.1, Retinoblastoma-binding protein 5, Histone-lysine N-methyltransferase 2A, WD repeat-containing protein 5, Set1/Ash2 histone methyltransferase complex subunit ASH2

Experimental Information Details

Resolution: 4.1Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C1
Microscope: FEI TITAN KRIOS
Detector: OTHER