EMDB EMD-0597

Single particle reconstruction
3.72Å resolution

Structure of a drug-like molecule stalled ribosome nascent chain complex (PCSK9-RNC) in rotated state with AA tRAN and PE tRNA

Map released:
Last modified:
Overview of EMD-0597
Source organism: Homo sapiens [9606]
Fitted atomic model: 6om7
Primary publication:
Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Li W, Ward FR, McClure KF, Chang ST, Montabana E, Liras S, Dullea RG, Cate JHD
Nat.Struct.Mol.Biol. 26 501-509 (2019)
PMID: 31160784

Function and Biology Details

Sample name: Drug-like molecule PF846 stalled human ribosome nascent chain complex, PCSK9-RNC in rotated state with AA tRNA and PE tRNA
Protein: Drug-like molecule PF846 stalled human ribosome nascent chain complex, PCSK9-RNC in rotated state with AA tRNA and PE tRNA

Experimental Information Details

Resolution: 3.72Å
Resolution method: FSC 0.143 CUT-OFF
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 SUMMIT (4k x 4k)