EMDB EMD-0541

Single particle reconstruction
4.1Å resolution

Structure of a MAPK pathway complex

Map released:
Overview of EMD-0541
Source organisms:
Fitted atomic model: 6nyb
To be published

Function and Biology Details

Sample name: Ternary complex of BRAF/MEK1/14-3-3 with MEK inhibitor
Ligands: PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ZINC ION, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide
Proteins: Ternary complex of BRAF/MEK1/14-3-3 with MEK inhibitor, Serine/threonine-protein kinase B-raf, Dual specificity mitogen-activated protein kinase kinase 1, 14-3-3 protein zeta

Experimental Information Details

Resolution: 4.1Å
Resolution method: FSC 0.143 CUT-OFF
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 SUMMIT (4k x 4k)