EMDB EMD-0452

Single particle reconstruction
3.7Å resolution

Cryo-EM structure of the human TFIIH core complex

Map released:
Overview of EMD-0452
Source organism: Human [9606]
Fitted atomic model: 6nmi
Primary publication:
The complete structure of the human TFIIH core complex
Greber BJ, Toso D, Fang J, Nogales E
Elife - (2019)

Function and Biology Details

Sample name: Transcription factor IIH (TFIIH)
Ligands: IRON/SULFUR CLUSTER, ZINC ION
Proteins: Transcription factor IIH (TFIIH), General transcription and DNA repair factor IIH helicase subunit XPB, General transcription and DNA repair factor IIH helicase subunit XPD, General transcription factor IIH subunit 1, p62, General transcription factor IIH subunit 4, p52, General transcription factor IIH subunit 2, p44, General transcription factor IIH subunit 3, p34, General transcription factor IIH subunit 5, p8, CDK-activating kinase assembly factor MAT1

Experimental Information Details

Resolution: 3.7Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C1
Reconstruction software: RELION
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 SUMMIT (4k x 4k)