Single particle reconstruction
3.9Å resolution

Cryo-EM structure of the BRISC complex bound to SHMT2

Map released:
Overview of EMD-0132
Source organism: Homo sapiens [9606]
Fitted atomic model: 6h3c
Primary publication:
Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.
Rabl J, Bunker RD, Schenk AD, Cavadini S, Gill ME, Abdulrahman W, Andres-Pons A, Luijsterburg MS, Ibrahim AFM, Branigan E, Aguirre JD, Marceau AH, Guerillon C, Bouwmeester T, Hassiepen U, Peters AHFM, Renatus M, Gelman L, Rubin SM, Mailand N, van Attikum H, Hay RT, Thoma NH
Mol.Cell - (2019)
PMID: 31253574

Function and Biology Details

Sample name: BRISC complex bound to SHMT2 alpha
Ligands: ZINC ION, water
Proteins: BRISC complex bound to SHMT2 alpha, BRISC complex, SHMT2 alpha, BRISC complex subunit Abraxas 2, Lys-63-specific deubiquitinase BRCC36, BRISC and BRCA1-A complex member 2, BRISC and BRCA1-A complex member 1, Serine hydroxymethyltransferase, mitochondrial

Experimental Information Details

Resolution: 3.9Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C2
Reconstruction software: RELION
Detector: GATAN K2 SUMMIT (4k x 4k)