Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-53880
The L1 amyloid-beta(1-40)fibril in the presence of anle138b (post-treatment)
EMD-53880
Helical reconstruction2.79 Å
Deposition: 21/05/2025Map released: 15/10/2025
Last modified: 15/10/2025
Sample Organism:
Homo sapiens
Sample: The L1 amyloid-beta(1-40)fibril in the presence of anle138b (post-treatment)
Fitted models: 9raw
Deposition Authors: Frieg B
,
Han M ,
Griesinger C ,
Schroeder GF
Sample: The L1 amyloid-beta(1-40)fibril in the presence of anle138b (post-treatment)
Fitted models: 9raw
Deposition Authors: Frieg B
,
Han M ,
Griesinger C ,
Schroeder GF
Anle138b binds predominantly to the central cavity in lipidic A beta 40 fibrils and modulates fibril formation.
Han M ,
Frieg B ,
Matthes D,
Leonov A,
Ryazanov S,
Giller K,
Nimerovsky E,
Stampolaki M,
Xue K,
Overkamp K,
Dienemann C ,
Riedel D,
Giese A,
Becker S ,
de Groot BL ,
Schroder GF ,
Andreas LB ,
Griesinger C
(2025) Nat Commun , 16 , 8850 - 8850
,
Frieg B ,
Matthes D,
Leonov A,
Ryazanov S,
Giller K,
Nimerovsky E,
Stampolaki M,
Xue K,
Overkamp K,
Dienemann C ,
Riedel D,
Giese A,
Becker S ,
de Groot BL ,
Schroder GF ,
Andreas LB ,
Griesinger C
(2025) Nat Commun , 16 , 8850 - 8850
Grant Support:
- Max Planck Society: (Germany)
- Helmholtz Association: (Germany)
- German Research Foundation (DFG): (Germany)