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EMD-52458
In vitro grown K58N Alpha-Synuclein Fibrils
EMD-52458
Single-particle3.7 Å
Deposition: 07/01/2025Map released: 12/02/2025
Last modified: 02/07/2025
Sample Organism:
Homo sapiens
Sample: Alpha-Synuclein K58N
Fitted models: 9hxa
Deposition Authors: Sicking K, Al-Azzani M
,
Outeiro TF,
Fernandez-Busnadiego R
Sample: Alpha-Synuclein K58N
Fitted models: 9hxa
Deposition Authors: Sicking K, Al-Azzani M
,
Outeiro TF,
Fernandez-Busnadiego R
A novel alpha-synuclein K58N missense variant in a patient with Parkinson's disease.
Al-Azzani M ,
Weber S,
Ramalingam N,
Ramon M,
Shvachiy L,
Mestre G,
Zech M,
Sicking K,
Ibanez de Opakua A,
Jayanthi V,
Amaral L,
Agarwal A,
Chandran A,
Chaves SR ,
Winkelmann J,
Trenkwalder C,
Schwager M,
Pauli S,
Dettmer U,
Fernandez CO,
Lautenschlager J,
Zweckstetter M,
Busnadiego RF,
Mollenhauer B,
Outeiro TF
(2025) Medrxiv
,
Weber S,
Ramalingam N,
Ramon M,
Shvachiy L,
Mestre G,
Zech M,
Sicking K,
Ibanez de Opakua A,
Jayanthi V,
Amaral L,
Agarwal A,
Chandran A,
Chaves SR ,
Winkelmann J,
Trenkwalder C,
Schwager M,
Pauli S,
Dettmer U,
Fernandez CO,
Lautenschlager J,
Zweckstetter M,
Busnadiego RF,
Mollenhauer B,
Outeiro TF
(2025) Medrxiv
Grant Support:
- German Research Foundation (DFG): EXC 2067/1-390729940 (Germany)
- German Research Foundation (DFG): SFB1286 (B8) (Germany)
- German Research Foundation (DFG): SFB1286 (A12) (Germany)
- German Research Foundation (DFG): 448415290 (Germany)
- Michael J. Fox Foundation: ASAP-000282 (United States)