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Articles
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New letters in the genetic code
Adding extra letters to the genetic code, in the form of non-natural nucleotides, makes it possible to encode 'exotic' amino acids in new codon triplets. |
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The more you bind, the less you need
The immune system is expert at identifying infected cells and destroying them. It can do this because molecules called the Major Histocompatibilty Complex (MHC) bind short peptides from the infecting virus or bacterium and display them on the cell's surface. |
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It takes two. HindIII needs two manganese ions at the active site.
PDB entries 3wvg, 3wvh, 3wvi, 3wvk and 3wvp |
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Mupain: Better binding with higher entropy
PDB entry: 4x1q The structure of a cyclic peptide, mupain, which acts as a protease inhibitor has been released this week, in several variants derived from a peptide library. |
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Structure of a left-handed DNA G-quadruplex.
PDB entry: 4u5m The iconic double helical structure of B-form DNA needs no introduction, but DNA can take on several different structures too. G-quadruplex DNA is formed from guanine-rich DNA sequences which are found in the telomeres. |
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Structure of an allergen from surgical gloves
PDB 4wp4: |
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Cryo-EM structure of the Dark apoptosome.
EMDB EMD-2871: The apoptosome, which comprises 16 molecules of the Dark protein, facilitates autocatalytic activation of caspase, which starts the process of apoptosis, or cell death. |
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FGFR1 with an inhibitor
PDB 4ux0: Fibroblast growth factor receptors (FGFRs) are recognized therapeutic targets in cancer. Structures released on 25th February describe insights underpinning the impact of mutations on these proteins on drug efficacy. |
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Human Retinoid X Receptor DNA-Binding Domain Bound to the Human Ramp2 Response Element.
PDB 4cn2: |
