Structure for inhibitor I32.007: BIRC-7 protein

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Pharma

PDB	Organism	Resolution	Comment
1OXN_A	Homo sapiens	2.20 Å	mature
Only one subunit is shown. The structural zinc atom is shown as a light grey CPK sphere. The zinc ligands are shown in ball-and-stick representation: Cys124, Cys127 and Cys151 in yellow, and His144 in purple.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Homo sapiens
NMR structure	0.00 Å	1F9X	1F9X	1F9X	1F9X	1F9X	1F9X	Sun et al., 2000
mature inhibitor	2.00 Å	1G73	1G73	1G73	1G73	1G73	1G73	Wu et al., 2000
mature inhibitor	2.40 Å	1I4O	1I4O	1I4O	1I4O	1I4O	1I4O	Huang et al., 2001
complex with caspase-7	2.90 Å	1KMC	1KMC	1KMC	1KMC	1KMC	1KMC
mature inhibitor	2.20 Å	1OXN	1OXN	1OXN	1OXN	1OXN	1OXN	Franklin et al., 2003
mature inhibitor	2.30 Å	1OXQ	1OXQ	1OXQ	1OXQ	1OXQ	1OXQ	Franklin et al., 2003
mature inhibitor	2.70 Å	1OY7	1OY7	1OY7	1OY7	1OY7	1OY7	Franklin et al., 2003
mature inhibitor	0.00 Å	1QBH	1QBH	1QBH	1QBH	1QBH	1QBH	Hinds et al., 1999
mature inhibitor	0.00 Å	1TFQ	1TFQ	1TFQ	1TFQ	1TFQ	1TFQ	Oost et al., 2004
mature inhibitor	0.00 Å	1TFT	1TFT	1TFT	1TFT	1TFT	1TFT	Oost et al., 2004
ML-IAP/XIAP chimera; complex with a nonomer peptide derived from smac	1.71 Å	1TW6	1TW6	1TW6	1TW6	1TW6	1TW6	Vucic et al., 2005
mature inhibitor	0.00 Å	2ECG	2ECG	2ECG	2ECG	2ECG	2ECG
ML-IAP/XIAP chimera; complex with a tetramer peptide (Ala-Val-Pro-Trp)	1.62 Å	2I3H	2I3H	2I3H	2I3H	2I3H	2I3H	Zobel et al., 2006
ML-IAP/XIAP chimera; complex with a peptidomimetic	2.30 Å	2I3I	2I3I	2I3I	2I3I	2I3I	2I3I	Zobel et al., 2006
XIAP-BIR3 domain; complex with a SMAC-mimetic compound	2.82 Å	2JK7	2JK7	2JK7	2JK7	2JK7	2JK7	Sun et al., 2008
mature inhibitor	0.00 Å	2KNA	2KNA	2KNA	2KNA	2KNA	2KNA	Hui et al., 2010
mature inhibitor	0.00 Å	2L9M	2L9M	2L9M	2L9M	2L9M	2L9M	Lopez et al., 2011
XIAP-BIR3 domain; complex with a SMAC-mimetic compound	2.80 Å	2OPY	2OPY	2OPY	2OPY	2OPY	2OPY	Wist et al., 2007
XIAP-BIR3 domain; complex with AVPF	3.00 Å	2OPZ	2OPZ	2OPZ	2OPZ	2OPZ	2OPZ	Wist et al., 2007
XIAP-BIR1 domain (i222 form)	1.80 Å	2POI	2POI	2POI	2POI	2POI	2POI	Lu et al., 2007
complex with TAB1	3.10 Å	2POP	2POP	2POP	2POP	2POP	2POP	Lu et al., 2007
XIAP-BIR1 domain (p21 form)	2.50 Å	2QRA	2QRA	2QRA	2QRA	2QRA	2QRA	Lin et al., 2007
XIAP-BIR3 domain; complex with a bivalent SMAC-mimetic compound	2.10 Å	2VSL	2VSL	2VSL	2VSL	2VSL	2VSL	Nikolovska-Coleska et al., 2008
XIAP-BIR3 domain; complex with a SMAC-mimetic compound, smac005	2.70 Å	3CLX	3CLX	3CLX	3CLX	3CLX	3CLX	Mastrangelo et al., 2008
XIAP-BIR3 domain; complex with a SMAC-mimetic compound, smac010 ***caveat 3cm2 chirality errors at cb of thr j355	2.50 Å	3CM2	3CM2	3CM2	3CM2	3CM2	3CM2	Mastrangelo et al., 2008
XIAP-BIR3 domain; complex with SMAC-mimetic compound, SMAC005	3.10 Å	3CM7	3CM7	3CM7	3CM7	3CM7	3CM7	Mastrangelo et al., 2008
CIAP1-BIR3 domain; complex with N-terminal peptide from caspase-9	1.50 Å	3D9T	3D9T	3D9T	3D9T	3D9T	3D9T	Kulathila et al., 2009
CIAP1-BIR3 domain; complex with N-terminal peptide from smac/diablo (avpiaq).	2.30 Å	3D9U	3D9U	3D9U	3D9U	3D9U	3D9U	Kulathila et al., 2009
mature inhibitor	2.00 Å	3EB5	3EB5	3EB5	3EB5	3EB5	3EB5	Mace et al., 2008
mature inhibitor	3.40 Å	3EB6	3EB6	3EB6	3EB6	3EB6	3EB6	Mace et al., 2008
XIAP-BIR3 domain; complex with a SMAC-mimetic compound	3.00 Å	3EYL	3EYL	3EYL	3EYL	3EYL	3EYL	Cossu et al., 2009
ML-IAP/XIAP chimera; complex with a peptidomimetic	1.80 Å	3F7H	3F7H	3F7H	3F7H	3F7H	3F7H	Vucic et al., 2005
ML-IAP/XIAP chimera; complex with a peptidomimetic	1.90 Å	3F7I	3F7I	3F7I	3F7I	3F7I	3F7I	Vucic et al., 2005
XIAP-BIR3 domain; complex with a bivalent compound	3.00 Å	3G76	3G76	3G76	3G76	3G76	3G76	Cossu et al., 2009
XIAP-BIR3 domain; complex with CS3	1.80 Å	3HL5	3HL5	3HL5	3HL5	3HL5	3HL5	Ndubaku et al., 2009
mature inhibitor	2.61 Å	3M0A	3M0A	3M0A	3M0A	3M0A	3M0A	Zheng et al., 2010
mature inhibitor	2.80 Å	3M0D	3M0D	3M0D	3M0D	3M0D	3M0D	Zheng et al., 2010
mature inhibitor	2.00 Å	3M1D	3M1D	3M1D	3M1D	3M1D	3M1D	Mace et al., 2010
mature inhibitor	2.60 Å	3MUP	3MUP	3MUP	3MUP	3MUP	3MUP	Cossu et al., 2010
mature inhibitor	3.00 Å	3OZ1	3OZ1	3OZ1	3OZ1	3OZ1	3OZ1	Cossu et al., 2010
mature inhibitor	1.90 Å	3T6P	3T6P	3T6P	3T6P	3T6P	3T6P	Dueber et al., 2011
mature inhibitor	1.79 Å	3UW4	3UW4	3UW4	3UW4	3UW4	3UW4	Flygare et al., 2012
mature inhibitor	1.79 Å	3UW4	3UW4	3UW4	3UW4	3UW4	3UW4	Flygare et al., 2012
mature inhibitor	1.71 Å	3UW5	3UW5	3UW5	3UW5	3UW5	3UW5	Flygare et al., 2012
mature inhibitor	2.60 Å	4EB9	4EB9	4EB9	4EB9	4EB9	4EB9	Cossu et al., 2012
mature inhibitor	3.30 Å	4EC4	4EC4	4EC4	4EC4	4EC4	4EC4	Cossu et al., 2012
mature inhibitor	2.84 Å	4HY0	4HY0	4HY0	4HY0	4HY0	4HY0	Hashimoto et al., 2013
mature inhibitor	1.25 Å	4HY4	4HY4	4HY4	4HY4	4HY4	4HY4	Hashimoto et al., 2013
mature inhibitor	1.75 Å	4HY5	4HY5	4HY5	4HY5	4HY5	4HY5	Hashimoto et al., 2013
mature inhibitor	2.20 Å	4IC2	4IC2	4IC2	4IC2	4IC2	4IC2	Nakatani et al., 2013
mature inhibitor	1.78 Å	4IC3	4IC3	4IC3	4IC3	4IC3	4IC3	Nakatani et al., 2013
mature inhibitor	1.45 Å	4J3Y	4J3Y	4J3Y	4J3Y	4J3Y	4J3Y	Lukacs et al., 2013
mature inhibitor	1.30 Å	4J44	4J44	4J44	4J44	4J44	4J44	Lukacs et al., 2013
mature inhibitor	1.48 Å	4J45	4J45	4J45	4J45	4J45	4J45	Lukacs et al., 2013
mature inhibitor	1.42 Å	4J46	4J46	4J46	4J46	4J46	4J46	Lukacs et al., 2013
mature inhibitor	1.35 Å	4J47	4J47	4J47	4J47	4J47	4J47	Lukacs et al., 2013
mature inhibitor	2.10 Å	4J48	4J48	4J48	4J48	4J48	4J48	Lukacs et al., 2013
mature inhibitor	1.60 Å	4KJU	4KJU	4KJU	4KJU	4KJU	4KJU	Kester et al., 2013
mature inhibitor	1.70 Å	4KJV	4KJV	4KJV	4KJV	4KJV	4KJV	Kester et al., 2013
mature inhibitor	1.52 Å	4KMN	4KMN	4KMN	4KMN	4KMN	4KMN
mature inhibitor	1.95 Å	4KMP	4KMP	4KMP	4KMP	4KMP	4KMP
mature inhibitor	1.55 Å	4LGE	4LGE	4LGE	4LGE	4LGE	4LGE	Asano et al., 2013
mature inhibitor	2.00 Å	4LGU	4LGU	4LGU	4LGU	4LGU	4LGU	Asano et al., 2013
mature inhibitor	2.15 Å	4MTI	4MTI	4MTI	4MTI	4MTI	4MTI	Shiokawa et al., 2013
mature inhibitor	2.10 Å	4MTZ	4MTZ	4MTZ	4MTZ	4MTZ	4MTZ
mature inhibitor	1.79 Å	4MU7	4MU7	4MU7	4MU7	4MU7	4MU7	Shiokawa et al., 2013
mature inhibitor	2.90 Å	4OXC	4OXC	4OXC	4OXC	4OXC	4OXC	Cossu et al., 2015
mature inhibitor	2.09 Å	4WVS	4WVS	4WVS	4WVS	4WVS	4WVS	Seigal et al., 2015
mature inhibitor	1.96 Å	4WVT	4WVT	4WVT	4WVT	4WVT	4WVT	Seigal et al., 2015
mature inhibitor	2.02 Å	4WVU	4WVU	4WVU	4WVU	4WVU	4WVU	Seigal et al., 2015
mature inhibitor	2.20 Å	5C0K	5C0K	5C0K	5C0K	5C0K	5C0K	Chessari et al., 2015
mature inhibitor	2.60 Å	5C0L	5C0L	5C0L	5C0L	5C0L	5C0L	Chessari et al., 2015
mature inhibitor	2.65 Å	5C3H	5C3H	5C3H	5C3H	5C3H	5C3H	Chessari et al., 2015
mature inhibitor	2.02 Å	5C3K	5C3K	5C3K	5C3K	5C3K	5C3K	Chessari et al., 2015
mature inhibitor	2.36 Å	5C7A	5C7A	5C7A	5C7A	5C7A	5C7A	Chessari et al., 2015
mature inhibitor	2.68 Å	5C7B	5C7B	5C7B	5C7B	5C7B	5C7B	Chessari et al., 2015
mature inhibitor	2.32 Å	5C7C	5C7C	5C7C	5C7C	5C7C	5C7C	Chessari et al., 2015
mature inhibitor	2.25 Å	5C7D	5C7D	5C7D	5C7D	5C7D	5C7D	Chessari et al., 2015
mature inhibitor	2.33 Å	5C83	5C83	5C83	5C83	5C83	5C83	Chessari et al., 2015
mature inhibitor	2.36 Å	5C84	5C84	5C84	5C84	5C84	5C84	Chessari et al., 2015
small molecule inhibitors of iap	2.32 Å	5M6E	5M6E	5M6E	5M6E	5M6E	5M6E
small molecule inhibitors of iap	2.39 Å	5M6F	5M6F	5M6F	5M6F	5M6F	5M6F
small molecule inhibitors of iap	2.50 Å	5M6H	5M6H	5M6H	5M6H	5M6H	5M6H
small molecule inhibitors of iap	2.61 Å	5M6L	5M6L	5M6L	5M6L	5M6L	5M6L
small molecule inhibitors of iap	2.37 Å	5M6M	5M6M	5M6M	5M6M	5M6M	5M6M
small molecule inhibitors of iap	1.80 Å	5M6N	5M6N	5M6N	5M6N	5M6N	5M6N
xiap in complex with small molecule	2.31 Å	5OQW	5OQW	5OQW	5OQW	5OQW	5OQW
crystal structure of ciap1-bir3 in complex with a covalently bound sm	2.20 Å	6EXW	6EXW	6EXW	6EXW	6EXW	6EXW
crystal structure of xiap-bir3 in complex with a ciap1-selective sm	2.70 Å	6EY2	6EY2	6EY2	6EY2	6EY2	6EY2
structure of xiap-bir1 domain in complex with an nf023 analog	1.90 Å	6GJW	6GJW	6GJW	6GJW	6GJW	6GJW
fragment derived xiap inhibitor	2.63 Å	6H6Q	6H6Q	6H6Q	6H6Q	6H6Q	6H6Q
fragment derived xiap inhibitor	2.03 Å	6H6R	6H6R	6H6R	6H6R	6H6R	6H6R
structure of xiap-bir1 v86e mutant	2.30 Å	6QCI	6QCI	6QCI	6QCI	6QCI	6QCI