Structure for inhibitor I02.001: aprotinin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature

PDB	Organism	Resolution	Comment
1BPI	Bos taurus	1.10 Å	mature
The reactive site residue Lys50 is shown in ball-and-stick representation in purple.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Bos taurus
30-51 disulfide mutant	1.60 Å	1AAL	1AAL	1AAL	1AAL	1AAL	1AAL	Eigenbrot et al., 1992
mature inhibitor	2.80 Å	1B0C	1B0C	1B0C	1B0C	1B0C	1B0C	Hamiaux et al., 2000
homodecamer	2.70 Å	1BHC	1BHC	1BHC	1BHC	1BHC	1BHC	Hamiaux et al., 1999
mature inhibitor	1.10 Å	1BPI	1BPI	1BPI	1BPI	1BPI	1BPI	Parkin et al., 1996
Tyr23Ala mutant	2.00 Å	1BPT	1BPT	1BPT	1BPT	1BPT	1BPT	Danishefsky et al., 1993
variant, complex with rat anionic trypsin I variant	2.10 Å	1BRB	1BRB	1BRB	1BRB	1BRB	1BRB	Perona et al., 1993
complex with human thrombin	2.30 Å	1BTH	1BTH	1BTH	1BTH	1BTH	1BTH	van et al., 1997
Phe22Ala mutant	2.20 Å	1BTI	1BTI	1BTI	1BTI	1BTI	1BTI	Danishefsky et al., 1993
mature inhibitor	2.58 Å	1BZ5	1BZ5	1BZ5	1BZ5	1BZ5	1BZ5	Hamiaux et al., 2000
mature inhibitor	2.10 Å	1BZX	1BZX	1BZX	1BZX	1BZX	1BZX	Helland et al., 1998
complex with chymotrypsin A	2.60 Å	1CBW	1CBW	1CBW	1CBW	1CBW	1CBW	Scheidig et al., 1997
complex with rat anionic trypsin	1.90 Å	1CO7	1CO7	1CO7	1CO7	1CO7	1CO7
complex with soft tick anticoagluant protein	1.62 Å	1D0D	1D0D	1D0D	1D0D	1D0D	1D0D	St et al., 2000
mature inhibitor	2.93 Å	1EAW	1EAW	1EAW	1EAW	1EAW	1EAW	Friedrich et al., 2002
mature inhibitor	1.85 Å	1EJM	1EJM	1EJM	1EJM	1EJM	1EJM	Grzesiak et al., 2000
mature inhibitor	1.65 Å	1F5R	1F5R	1F5R	1F5R	1F5R	1F5R	Pasternak et al., 2001
mature inhibitor	1.55 Å	1F7Z	1F7Z	1F7Z	1F7Z	1F7Z	1F7Z	Pasternak et al., 2001
complex with tissue factor and coagulation factor VII	2.10 Å	1FAK	1FAK	1FAK	1FAK	1FAK	1FAK	Zhang et al., 1999
Phe45Ala mutant	1.95 Å	1FAN	1FAN	1FAN	1FAN	1FAN	1FAN	Danishefsky et al., 1993
mature inhibitor	1.70 Å	1FY8	1FY8	1FY8	1FY8	1FY8	1FY8	Pasternak et al., 2001
Ala11Thr, Ala13Pro, Arg15Lys and Leu52Met mutant	0.86 Å	1G6X	1G6X	1G6X	1G6X	1G6X	1G6X	Addlagatta et al., 2001
NMR structure; Gly37Ala mutant	0.00 Å	1JV8	1JV8	1JV8	1JV8	1JV8	1JV8	Battiste et al., 2002
NMR structure; Gly37Ala mutant	0.00 Å	1JV9	1JV9	1JV9	1JV9	1JV9	1JV9	Battiste et al., 2002
NMR structure; synthetic BetaCore peptide	0.00 Å	1K09	1K09	1K09	1K09	1K09	1K09	Carulla et al., 2002
cyclic form	1.00 Å	1K6U	1K6U	1K6U	1K6U	1K6U	1K6U	Botos et al., 2001
NMR structure; Ala16Val mutant	0.00 Å	1LD5	1LD5	1LD5	1LD5	1LD5	1LD5	Cierpicki & Otlewski, 2002
NMR structure; 8A mutant	0.00 Å	1LD6	1LD6	1LD6	1LD6	1LD6	1LD6	Cierpicki & Otlewski, 2002
complex with chymotrypsin A	2.80 Å	1MTN	1MTN	1MTN	1MTN	1MTN	1MTN	Capasso et al., 1997
Asn43Gly mutant	1.85 Å	1NAG	1NAG	1NAG	1NAG	1NAG	1NAG	Danishefsky et al., 1993
mature inhibitor	0.00 Å	1OA5	1OA5	1OA5	1OA5	1OA5	1OA5	Williamson et al., 2003
mature inhibitor	0.00 Å	1OA6	1OA6	1OA6	1OA6	1OA6	1OA6	Williamson et al., 2003
structural consequences of accommodation of four non- cognate amino-acid residues in the s1 pocket of bovine trypsin and chymotrypsin	1.65 Å	1P2I	1P2I	1P2I	1P2I	1P2I	1P2I	Helland et al., 2003
structural consequences of accommodation of four non- cognate amino-acid residues in the s1 pocket of bovine trypsin and chymotrypsin	1.35 Å	1P2J	1P2J	1P2J	1P2J	1P2J	1P2J	Helland et al., 2003
structural consequences of accommodation of four non- cognate amino-acid residues in the s1 pocket of bovine trypsin and chymotrypsin	1.60 Å	1P2K	1P2K	1P2K	1P2K	1P2K	1P2K	Helland et al., 2003
complex with chymotrypsin A	1.75 Å	1P2M	1P2M	1P2M	1P2M	1P2M	1P2M	Helland et al., 2003
complex with chymotrypsin A	1.80 Å	1P2N	1P2N	1P2N	1P2N	1P2N	1P2N	Helland et al., 2003
comlex with chymotrypsin A	2.00 Å	1P2O	1P2O	1P2O	1P2O	1P2O	1P2O	Helland et al., 2003
complex with chymotrypsin A	1.80 Å	1P2Q	1P2Q	1P2Q	1P2Q	1P2Q	1P2Q	Helland et al., 2003
NMR structure	0.00 Å	1PIT	1PIT	1PIT	1PIT	1PIT	1PIT	Berndt et al., 1992
Ala11Thr, Ala13Pro, Arg15Lys and Leu52Met mutant	1.42 Å	1QLQ	1QLQ	1QLQ	1QLQ	1QLQ	1QLQ	Czapinska et al., 2000
P1 Glu mutant; complex with chymotrypsin A	1.85 Å	1T7C	1T7C	1T7C	1T7C	1T7C	1T7C	Czapinska et al., 2004
P1 Met mutant; complex with chymotrypsin A	1.75 Å	1T8L	1T8L	1T8L	1T8L	1T8L	1T8L	Czapinska et al., 2004
P1 His mutant; complex with chymotrypsin A	1.80 Å	1T8M	1T8M	1T8M	1T8M	1T8M	1T8M	Czapinska et al., 2004
P1 Thr mutant; complex with chymotrypsin A	1.75 Å	1T8N	1T8N	1T8N	1T8N	1T8N	1T8N	Czapinska et al., 2004
P1 Trp mutant; complex with chymotrypsin A	1.70 Å	1T8O	1T8O	1T8O	1T8O	1T8O	1T8O	Czapinska et al., 2004
complex with anhydro-trypsin	1.90 Å	1TPA	1TPA	1TPA	1TPA	1TPA	1TPA
NMR structure	0.00 Å	1UUA	1UUA	1UUA	1UUA	1UUA	1UUA
NMR structure	0.00 Å	1UUB	1UUB	1UUB	1UUB	1UUB	1UUB
mutant; complex with trypsin	1.70 Å	1YKT	1YKT	1YKT	1YKT	1YKT	1YKT	Getun et al., 2008
mutant; complex with trypsin	1.70 Å	1YLC	1YLC	1YLC	1YLC	1YLC	1YLC	Getun et al., 2008
mutant; complex with trypsin	1.70 Å	1YLD	1YLD	1YLD	1YLD	1YLD	1YLD	Getun et al., 2008
Cys14Ser, Cys38Ser variant; complex with trypsin	1.58 Å	2FI3	2FI3	2FI3	2FI3	2FI3	2FI3	Zakharova et al., 2008
Cys14Ser variant; complex with trypsin	1.58 Å	2FI4	2FI4	2FI4	2FI4	2FI4	2FI4	Zakharova et al., 2008
Cys38Ser variant; complex with trypsin	1.58 Å	2FI5	2FI5	2FI5	2FI5	2FI5	2FI5	Zakharova et al., 2008
complex with trypsin	1.62 Å	2FTL	2FTL	2FTL	2FTL	2FTL	2FTL	Hanson et al., 2007
Tyr35Gly variant; complex with trypsin	1.65 Å	2FTM	2FTM	2FTM	2FTM	2FTM	2FTM	Hanson et al., 2007
decamer	2.10 Å	2HEX	2HEX	2HEX	2HEX	2HEX	2HEX	Lubkowski & Wlodawer, 1999
complex with West Nile virus NS2B-NS3 proteins	2.30 Å	2IJO	2IJO	2IJO	2IJO	2IJO	2IJO	Aleshin et al., 2007
complex with pig tissue kallikrein	2.50 Å	2KAI	2KAI	2KAI	2KAI	2KAI	2KAI	Chen & Bode, 1983
complex with cattle cationic trypsin	1.90 Å	2PTC	2PTC	2PTC	2PTC	2PTC	2PTC
complex with human mesotrypsin	1.40 Å	2R9P	2R9P	2R9P	2R9P	2R9P	2R9P	Salameh et al., 2008
human cationic trypsin complexed with bovine pancreatic trypsin inhibitor (bpti)	1.46 Å	2RA3	2RA3	2RA3	2RA3	2RA3	2RA3	Salameh et al., 2008
complex with cattle cationic trypsinogen	1.90 Å	2TGP	2TGP	2TGP	2TGP	2TGP	2TGP
complex with cattle cationic trypsinogen	2.10 Å	2TPI	2TPI	2TPI	2TPI	2TPI	2TPI
mature inhibitor	1.09 Å	2ZJX	2ZJX	2ZJX	2ZJX	2ZJX	2ZJX	Islam et al., 2008
mature inhibitor	1.09 Å	2ZVX	2ZVX	2ZVX	2ZVX	2ZVX	2ZVX	Islam et al., 2009
mature inhibitor	1.90 Å	3BTD	3BTD	3BTD	3BTD	3BTD	3BTD	Helland et al., 1999
mature inhibitor	1.85 Å	3BTE	3BTE	3BTE	3BTE	3BTE	3BTE	Helland et al., 1999
mature inhibitor	1.80 Å	3BTF	3BTF	3BTF	3BTF	3BTF	3BTF	Helland et al., 1999
mature inhibitor	1.90 Å	3BTG	3BTG	3BTG	3BTG	3BTG	3BTG	Helland et al., 1999
mature inhibitor	1.75 Å	3BTH	3BTH	3BTH	3BTH	3BTH	3BTH	Helland et al., 1999
mature inhibitor	1.85 Å	3BTK	3BTK	3BTK	3BTK	3BTK	3BTK	Helland et al., 1999
mature inhibitor	1.80 Å	3BTM	3BTM	3BTM	3BTM	3BTM	3BTM	Helland et al., 1999
mature inhibitor	1.90 Å	3BTQ	3BTQ	3BTQ	3BTQ	3BTQ	3BTQ	Helland et al., 1999
mature inhibitor	1.90 Å	3BTT	3BTT	3BTT	3BTT	3BTT	3BTT	Helland et al., 1999
mature inhibitor	2.05 Å	3BTW	3BTW	3BTW	3BTW	3BTW	3BTW	Helland et al., 1999
complex with anionic trypsin	1.49 Å	3FP6	3FP6	3FP6	3FP6	3FP6	3FP6	Zakharova et al., 2009
cleaved form (Lys15+Ala16); complex with anionic trypsin mutant Ser195Ala	1.46 Å	3FP7	3FP7	3FP7	3FP7	3FP7	3FP7	Zakharova et al., 2009
complex with anionic trypsin mutant Ser195Ala	1.46 Å	3FP8	3FP8	3FP8	3FP8	3FP8	3FP8	Zakharova et al., 2009
complex with prostasin	2.80 Å	3GYM	3GYM	3GYM	3GYM	3GYM	3GYM	Spraggon et al., 2009
mature inhibitor	2.20 Å	3LDI	3LDI	3LDI	3LDI	3LDI	3LDI	Yang et al., 2010
mature inhibitor	1.70 Å	3LDJ	3LDJ	3LDJ	3LDJ	3LDJ	3LDJ	Yang et al., 2010
mature inhibitor	2.60 Å	3LDM	3LDM	3LDM	3LDM	3LDM	3LDM	Yang et al., 2010
mature inhibitor	2.15 Å	3OTJ	3OTJ	3OTJ	3OTJ	3OTJ	3OTJ	Kawamura et al., 2011
mature inhibitor	1.60 Å	3P92	3P92	3P92	3P92	3P92	3P92	Salameh et al., 2011
mature inhibitor	1.30 Å	3P95	3P95	3P95	3P95	3P95	3P95	Salameh et al., 2011
complex with rat anionic trypsin II	1.80 Å	3TGI	3TGI	3TGI	3TGI	3TGI	3TGI	Pasternak et al., 1999
complex with rat anionic trypsin II, Ser195Ala mutant	2.20 Å	3TGJ	3TGJ	3TGJ	3TGJ	3TGJ	3TGJ	Pasternak et al., 1999
mature inhibitor	1.70 Å	3TGK	3TGK	3TGK	3TGK	3TGK	3TGK	Pasternak et al., 2001
complex with cattle cationic trypsinogen	1.90 Å	3TPI	3TPI	3TPI	3TPI	3TPI	3TPI
mature inhibitor	1.80 Å	3U1J	3U1J	3U1J	3U1J	3U1J	3U1J	Noble et al., 2012
mature inhibitor	1.30 Å	3WNY	3WNY	3WNY	3WNY	3WNY	3WNY
mature inhibitor	2.00 Å	4BNR	4BNR	4BNR	4BNR	4BNR	4BNR	Molnar et al., 2013
mature inhibitor	1.40 Å	4DG4	4DG4	4DG4	4DG4	4DG4	4DG4	Salameh et al., 2012
mature inhibitor	1.50 Å	4PTI	4PTI	4PTI	4PTI	4PTI	4PTI
complex with cattle cationic trypsinogen	2.20 Å	4TPI	4TPI	4TPI	4TPI	4TPI	4TPI	Bode et al., 1984
mature inhibitor	1.70 Å	4WWY	4WWY	4WWY	4WWY	4WWY	4WWY	Alloy et al., 2015
mature inhibitor	2.10 Å	4WXV	4WXV	4WXV	4WXV	4WXV	4WXV	Alloy et al., 2015
mature inhibitor	1.25 Å	4Y0Y	4Y0Y	4Y0Y	4Y0Y	4Y0Y	4Y0Y
mature inhibitor	1.37 Å	4Y0Z	4Y0Z	4Y0Z	4Y0Z	4Y0Z	4Y0Z
mature inhibitor	1.37 Å	4Y10	4Y10	4Y10	4Y10	4Y10	4Y10
mature inhibitor	1.30 Å	4Y11	4Y11	4Y11	4Y11	4Y11	4Y11
a simplified bpti variant containing 21 alanines out of 58 residues	1.99 Å	5JB4	5JB4	5JB4	5JB4	5JB4	5JB4
a simplified bpti variant containing 22 alanines out of 58 residues	1.60 Å	5JB5	5JB5	5JB5	5JB5	5JB5	5JB5
a simplified bpti variant containing 23 alanines out of 58 residues	1.90 Å	5JB6	5JB6	5JB6	5JB6	5JB6	5JB6
a simplified bpti variant containing 24 alanines out of 58 residues	1.90 Å	5JB7	5JB7	5JB7	5JB7	5JB7	5JB7
crystal form II	1.00 Å	5PTI	5PTI	5PTI	5PTI	5PTI	5PTI	Wlodawer et al., 1984
Cys14Gly/Ala38Leu mutant	1.12 Å	5XX2	5XX2	5XX2	5XX2	5XX2	5XX2
Cys14Gly/Ala38Gly mutant	1.12 Å	5XX3	5XX3	5XX3	5XX3	5XX3	5XX3
Cys14Gly/Ala38Lys mutant	1.67 Å	5XX4	5XX4	5XX4	5XX4	5XX4	5XX4
Cys14Gly/Ala38Ile mutant	1.38 Å	5XX5	5XX5	5XX5	5XX5	5XX5	5XX5
hetero-micro-seeding: crystal structure of bpti-[5,55]c14ga38i variantusing micro-seeds from -c14ga38g variant	1.31 Å	5XX6	5XX6	5XX6	5XX6	5XX6	5XX6
hetero-micro-seeding: crystal structure of bpti-[5,55]c14ga38i variantusing micro-seeds from -c14ga38i variant	1.38 Å	5XX7	5XX7	5XX7	5XX7	5XX7	5XX7
hetero-micro-seeding: crystal structure of bpti-[555]c14ga38i variant using micro-seeds from -c14ga38l variant	1.30 Å	5XX8	5XX8	5XX8	5XX8	5XX8	5XX8
crystal structures of unlinked full length ns3 from dengue virus provide insights into dynamics of protease domain	2.49 Å	5YVU	5YVU	5YVU	5YVU	5YVU	5YVU
complex with full length ns3 protein (ed4ns2bns3)	2.60 Å	5YW1	5YW1	5YW1	5YW1	5YW1	5YW1
the methylene thioacetal bpti (bovine pancreatic trypsin inhibitor) mutant structure	1.72 Å	6F1F	6F1F	6F1F	6F1F	6F1F	6F1F
mature inhibitor	1.70 Å	6PTI	6PTI	6PTI	6PTI	6PTI	6PTI	Wlodawer et al., 1987
Cys30Ala, Cys51Ala mutant	1.60 Å	7PTI	7PTI	7PTI	7PTI	7PTI	7PTI	Eigenbrot et al., 1990
Tyr35Gly mutant	1.80 Å	8PTI	8PTI	8PTI	8PTI	8PTI	8PTI	Housset et al., 1991
Tyr35Gly mutant	1.22 Å	9PTI	9PTI	9PTI	9PTI	9PTI	9PTI