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Literature for inhibitor I02.001: aprotinin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature

(Topics flags: S Structure, P Specificity, I Inhibitor, L Localization, E Expression, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Nazir,F., Munir,I. and Yesiloz,G.
    A Microfluidics-Assisted Double-Barreled Nanobioconjugate Synthesis Introducing Aprotinin as a New Moonlight Nanocarrier Protein: Tested toward Physiologically Relevant 3D-Spheroid Models
    ACS Appl Mater Interfaces16, 18311-18326. PubMed  Europe PubMed DOI
    2. 2023
  2. Ivachtchenko,A.V., Ivashchenko,A.A., Shkil,D.O. and Ivashchenko,I.A.
    Aprotinin-Drug against Respiratory Diseases
    Int J Mol Sci24, PubMed  Europe PubMed DOI  V
  3. Roy,U.C. and Bandyopadhyay,P.
    Correlation between protein conformations and water structure and thermodynamics at high pressure: A molecular dynamics study of the Bovine Pancreatic Trypsin Inhibitor (BPTI) protein
    J Chem Phys158, 095102-095102. PubMed  Europe PubMed DOI
    4. 2022
  4. Leppkes,J., Dimos,N., Loll,B., Hohmann,T., Dyrks,M., Wieseke,A., Keller,B.G. and Koksch,B.
    Fluorine-induced polarity increases inhibitory activity of BPTI towards chymotrypsin
    RSC Chem Biol3, 773-782. PubMed  Europe PubMed DOI
    5. 2020
  5. Bojkova,D., Bechtel,M., McLaughlin,K.M., McGreig,J.E., Klann,K., Bellinghausen,C., Rohde,G., Jonigk,D., Braubach,P., Ciesek,S., Munch,C., Wass,M.N., Michaelis,M. and Cinatl,J., Jr.
    Aprotinin Inhibits SARS-CoV-2 Replication
    Cells9, PubMed  Europe PubMed DOI
  6. de Almeida,A.D., Silva,I.S., Fernandes-Braga,W., LimaFilho,A.C.M., Florentino,R.O.M., Barra,A., de Oliveira Andrade,L., Leite,M.F., Cassali,G.D. and Klein,A.
    A role for mast cells and mast cell tryptase in driving neutrophil recruitment in LPS-induced lung inflammation via protease-activated receptor 2 in mice
    Inflamm Res PubMed  Europe PubMed DOI
  7. Kahler,U., Kamenik,A.S., Waibl,F., Kraml,J. and Liedl,K.R.
    Protein-Protein Binding as a Two-Step Mechanism: Preselection of Encounter Poses during the Binding of BPTI and Trypsin
    Biophys J119, 652-666. PubMed  Europe PubMed DOI
  8. Shi,J.Y., Pan,H.Y., Liu,K., Pan,M. and Si,G.J.
    Expression of ectopic trypsin in atherosclerotic plaques and the effects of aprotinin on plaque stability
    Arch Biochem Biophys690, 108460-108460. PubMed  Europe PubMed DOI
    9. 2019
  9. Agic,D., Brkic,H., Kazazic,S., Tomic,A. and Abramic,M.
    Aprotinin interacts with substrate-binding site of human dipeptidyl peptidase III
    J Biomol Struct Dyn37, 3596-3606. PubMed  Europe PubMed DOI
  10. Sasaki,Y., Sato,Y., Takahashi,T., Umetsu,M. and Iki,N.
    Capillary electrophoretic reactor for estimation of spontaneous dissociation rate of trypsin-aprotinin complex
    Anal Biochem585, 113406-113406. PubMed  Europe PubMed DOI
  11. Soleyman-Jahi,S., Sadeghi,F., Afshari,Z., Barati,T., Ghasemi,S., Muhammadnejad,S., Amanpour,S. and Zendehdel,K.
    Anti-neoplastic effects of aprotinin on human breast cancer cell lines: in vitro study
    Adv Clin Exp Med28, 151-157. PubMed  Europe PubMed DOI
    12. 2018
  12. Mousa,R., Lansky,S., Shoham,G. and Metanis,N.
    BPTI folding revisited: switching a disulfide into methylene thioacetal reveals a previously hidden path
    Chem Sci9, 4814-4820. PubMed  Europe PubMed DOI  S
    13. 2017
  13. Deloge,E., Amour,J., Provenchere,S., Rozec,B., Scherrer,B. and Ouattara,A.
    Aprotinin vs. tranexamic acid in isolated coronary artery bypass surgery: a multicentre observational study
    Eur J Anaesthesiol34, 280-287. PubMed  Europe PubMed DOI  I
    14. 2016
  14. Ang,M.J., Lim,H.A., Poulsen,A., Wee,J.L., Ng,F.M., Joy,J., Hill,J. and Chia,C.S.
    Miniature bovine pancreatic trypsin inhibitors (m-BPTIs) of the West Nile virus NS2B-NS3 protease
    J Enzyme Inhib Med Chem31, 194-200. PubMed  Europe PubMed DOI  I
    15. 2015
  15. Brannon,J.R., Burk,D.L., Leclerc,J.M., Thomassin,J.L., Portt,A., Berghuis,A.M., Gruenheid,S. and Le Moual,H.
    Inhibition of outer membrane proteases of the omptin family by aprotinin
    Infect Immun83, 2300-2311. PubMed  Europe PubMed DOI
  16. Karasulu,H.Y., Oruc,N., Ustundag-Okur,N., Ilem Ozdemir,D., Ay Senyigit,Z., Barbet Yilmaz,F., Asikoglu,M., Ozkilic,H., Akcicek,E., Guneri,T. and Ozutemiz,O.
    Aprotinin revisited: formulation, characterization, biodistribution and therapeutic potential of new aprotinin microemulsion in acute pancreatitis
    J Drug Target23, 525-537. PubMed  Europe PubMed DOI  U
  17. Royston,D.
    The current place of aprotinin in the management of bleeding
    Anaesthesia70 Suppl 1, 46-49. PubMed  Europe PubMed DOI
  18. Xin,Y., Liu,L., Chen,B., Zhang,L. and Tong,Y.
    Affinity purification of aprotinin from bovine lung
    J Sep Sci38, 1441-1448. PubMed  Europe PubMed DOI
  19. Ye,S., Loll,B., Berger,A.A., Mulow,U., Alings,C., Wahl,M.C. and Koksch,B.
    Fluorine teams up with water to restore inhibitor activity to mutant BPTI
    Chem Sci6, 5246-5254. PubMed  Europe PubMed DOI
    20. 2014
  20. Chen,W.N., Loscha,K.V., Nitsche,C., Graham,B. and Otting,G.
    The dengue virus NS2B-NS3 protease retains the closed conformation in the complex with BPTI
    FEBS Lett588, 2206-2211. PubMed  Europe PubMed DOI
  21. Li,H., Zhu,L., Hou,S., Yang,J., Wang,J. and Liu,J.
    An inhibition model of BPTI to unlinked dengue virus NS2B-NS3 protease
    FEBS Lett588, 2794-2799. PubMed  Europe PubMed DOI  S
    22. 2013
  22. Beckerman,Z., Shopen,Y., Alon,H., Cohen,O., Nir,R.R., Adler,Z. and Bolotin,G.
    Coronary artery bypass grafting after aprotinin: are we doing better?
    J Thorac Cardiovasc Surg145, 243-248. PubMed  Europe PubMed DOI  U
  23. Ferraris,V.A.
    Facts, opinions, and conclusions: aprotinin brings out all of these
    J Thorac Cardiovasc Surg145, 240-242. PubMed  Europe PubMed DOI
  24. Howell,N., Senanayake,E., Freemantle,N. and Pagano,D.
    Putting the record straight on aprotinin as safe and effective: results from a mixed treatment meta-analysis of trials of aprotinin
    J Thorac Cardiovasc Surg145, 234-240. PubMed  Europe PubMed DOI
  25. Liu,F., Ye,M., Wang,C., Hu,Z., Zhang,Y., Qin,H., Cheng,K. and Zou,H.
    Polyacrylamide gel with switchable trypsin activity for analysis of proteins
    Anal Chem85, 7024-7028. PubMed  Europe PubMed DOI
  26. Martin,K., Gertler,R., Macguill,M., Mayr,N.P., Hapfelmeier,A., Horer,J., Vogt,M., Tassani,P. and Wiesner,G.
    Replacement of aprotinin by epsilon-aminocaproic acid in infants undergoing cardiac surgery: Consequences for blood loss and outcome
    Br J Anaesth110, 615-621. PubMed  Europe PubMed DOI  I
  27. McMullan,V. and Alston,R.P.
    III. Aprotinin and cardiac surgery: a sorry tale of evidence misused
    Br J Anaesth110, 675-678. PubMed  Europe PubMed DOI  V
  28. Molnar,T., Voros,J., Szeder,B., Takats,K., Kardos,J., Katona,G. and Graf,L.
    Comparison of complexes formed by a crustacean and a vertebrate trypsin with bovine pancreatic trypsin inhibitor - the key to achieving extreme stability?
    FEBS J280, 5750-5763. PubMed  Europe PubMed DOI
    29. 2012
  29. Deanda,A., Jr. and Spiess,B.D.
    Aprotinin revisited
    J Thorac Cardiovasc Surg144, 998-1002. PubMed  Europe PubMed DOI  U
  30. Graham,E.M., Atz,A.M., Gillis,J., Desantis,S.M., Haney,A.L., Deardorff,R.L., Uber,W.E., Reeves,S.T., McGowan,F.X., Jr., Bradley,S.M. and Spinale,F.G.
    Differential effects of aprotinin and tranexamic acid on outcomes and cytokine profiles in neonates undergoing cardiac surgery
    J Thorac Cardiovasc Surg143, 1069-1076. PubMed  Europe PubMed DOI  U  I
  31. Salameh,M.A., Soares,A.S., Alloy,A. and Radisky,E.S.
    Presence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitors
    Protein Sci21, 1103-1112. PubMed  Europe PubMed DOI  S
    32. 2011
  32. Chang,J.Y.
    Distinct folding pathways of two homologous disulfide proteins: bovine pancreatic trypsin inhibitor and tick anticoagulant peptide
    Antioxid Redox Signal14, 127-135. PubMed  Europe PubMed DOI
  33. Kawamura,K., Yamada,T., Kurihara,K., Tamada,T., Kuroki,R., Tanaka,I., Takahashi,H. and Niimura,N.
    X-ray and neutron protein crystallographic analysis of the trypsin-BPTI complex
    Acta Crystallogr D Biol Crystallogr67, 140-148. PubMed  Europe PubMed DOI  S
  34. Trzebicki,J., Kosieradzki,M., Flakiewicz,E., Kuzminska,G., Wasiak,D., Pacholczyk,M., Lagiewska,B., Lisik,W., Kosson,D., Kulik,A., Chmura,A. and Lazowski,T.
    Detrimental effect of aprotinin ban on amount of blood loss during liver transplantation: single-center experience
    Transplant Proc43, 1725-1727. PubMed  Europe PubMed DOI
  35. Viswanathan,A., Kuriakose,B., Bharadwaj,S. and Thomas,G.
    Expression of aprotinin in anther causes male sterility in tobacco var Petit Havana
    Plant Mol Biol Report29, 825-834. DOI
  36. Zhirnov,O.P., Matrosovich,T.Y., Matrosovich,M.N. and Klenk,H.D.
    Aprotinin, a protease inhibitor, suppresses proteolytic activation of pandemic H1N1v influenza virus
    Antiviral Chem Chemother21, 245- DOI
  37. Zhirnov,O.P., Klenk,H.D. and Wright,P.F.
    Aprotinin and similar protease inhibitors as drugs against influenza
    Antiviral Res92, 27-36. PubMed  Europe PubMed DOI
    38. 2010
  38. Ide,M., Bolliger,D., Taketomi,T. and Tanaka,K.A.
    Lessons from the aprotinin saga: current perspective on antifibrinolytic therapy in cardiac surgery
    J Anesth24, 96-106. PubMed  Europe PubMed DOI
  39. Kawamura,K., Yamada,T., Kurihara,K., Tamada,T., Kuroki,R., Tanaka,I., Takahashi,H. and Niimura,N.
    A preliminary neutron crystallography on the trypsin-bovine pancreatic trypsin inhibitor complex
    J Phys Conf Ser251, 012033-012033. DOI  S
  40. McMullan,V. and Alston,R.P.
    The effect of the suspension of the license for aprotinin on the care of patients undergoing cardiac surgery: a survey of cardiac anesthesiologists' and surgeons' opinions in the united kingdom
    J Cardiothorac Vasc Anesth24, 418-421. PubMed  Europe PubMed DOI  U
  41. Navaneetham,D., Sinha,D. and Walsh,P.N.
    Mechanisms and specificity of factor XIa and trypsin inhibition by protease nexin 2 and basic pancreatic trypsin inhibitor
    J Biochem148, 467-479. PubMed  Europe PubMed DOI
  42. Salameh,M.A., Soares,A.S., Navaneetham,D., Sinha,D., Walsh,P.N. and Radisky,E.S.
    Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin
    J Biol Chem285, 36884-36896. PubMed  Europe PubMed DOI
  43. Smith,M., Kocher,H.M. and Hunt,B.J.
    Aprotinin in severe acute pancreatitis
    Int J Clin Pract64, 84-92. PubMed  Europe PubMed DOI  V
  44. Yang,I.S., Kim,T.G., Park,B.S., Cho,K.J., Lee,J.H., Park,Y. and Kim,K.H.
    Crystal structures of aprotinin and its complex with sucrose octasulfate reveal multiple modes of interactions with implications for heparin binding
    Biochem Biophys Res Commun397, 429-435. PubMed  Europe PubMed DOI  S
    45. 2009
  45. Christy,L.A., Arvinth,S., Saravanakumar,M., Kanchana,M., Mukunthan,N., Srikanth,J., Thomas,G. and Subramonian,N.
    Engineering sugarcane cultivars with bovine pancreatic trypsin inhibitor (aprotinin) gene for protection against top borer (Scirpophaga excerptalis Walker)
    Plant Cell Rep28, 175-184. PubMed  Europe PubMed DOI  E
  46. Dietrich,W.
    Aprotinin: 1 year on
    Curr Opin Anaesthesiol22, 121-127. PubMed  Europe PubMed DOI
  47. Meta,A., Nakatake,H., Imamura,T., Nozaki,C. and Sugimura,K.
    High-yield production and characterization of biologically active recombinant aprotinin expressed in Saccharomyces cerevisiae
    Protein Expr Purif66, 22-27. PubMed  Europe PubMed DOI  E
  48. Sun,Z., Lu,W., Jiang,A., Chen,J., Tang,F. and Liu,J.N.
    Expression, purification and characterization of aprotinin and a human analogue of aprotinin
    Protein Expr Purif65, 238-243. PubMed  Europe PubMed DOI  E
  49. Yabe,K. and Koide,T.
    Inhibition of the 20S proteosome by a protein proteinase inhibitor: evidence that a natural serine proteinase inhibitor can inhibit a threonine proteinase
    J Biochem145, 217-227. PubMed  Europe PubMed DOI
  50. Zakharova,E., Horvath,M.P. and Goldenberg,D.P.
    Structure of a serine protease poised to resynthesize a peptide bond
    Proc Natl Acad Sci U S A106, 11034-11039. PubMed  Europe PubMed DOI
    51. 2008
  51. de Cassia Dias,S., Sakauchi,D., Abreu,P.A., de Lima Netto,S., Iourtov,D., Raw,I. and Kubrusly,F.S.
    Purification and characterization of aprotinin from porcine lungs
    Biotechnol Lett30, 807-812. PubMed  Europe PubMed DOI
  52. Getun,I.V., Brown,C.K., Tulla-Puche,J., Ohlendorf,D., Woodward,C. and Barany,G.
    Partially folded bovine pancreatic trypsin inhibitor analogues attain fully native structures when co-crystallized with S195A rat trypsin
    J Mol Biol375, 812-823. PubMed  Europe PubMed DOI  S
  53. Salameh,M.A., Soares,A.S., Hockla,A. and Radisky,E.S.
    Structural basis for accelerated cleavage of bovine pancreatic trypsin inhibitor (BPTI) by human mesotrypsin
    J Biol Chem283, 4115-4123. PubMed  Europe PubMed DOI
  54. Westaby,S.
    Aprotinin: twenty-five years of claim and counterclaim
    J Thorac Cardiovasc Surg135, 487-491. PubMed  Europe PubMed DOI  V
  55. Yang,L., Dong,W., He,J., Ren,X. and Yan,W.
    Expression and purification of natural N-terminal recombinant bovine pancreatic trypsin inhibitor from Pichia pastoris
    Biol Pharm Bull31, 1680-1685. PubMed  Europe PubMed DOI  E
  56. Zakharova,E., Horvath,M.P. and Goldenberg,D.P.
    Functional and structural roles of the Cys14-Cys38 disulfide of bovine pancreatic trypsin inhibitor
    J Mol Biol382, 998-1013. PubMed  Europe PubMed DOI
    57. 2007
  57. Hanson,W.M., Domek,G.J., Horvath,M.P. and Goldenberg,D.P.
    Rigidification of a flexible protease inhibitor variant upon binding to trypsin
    J Mol Biol366, 230-243. PubMed  Europe PubMed DOI
  58. Mueller,N.H., Yon,C., Ganesh,V.K. and Padmanabhan,R.
    Characterization of the West Nile virus protease substrate specificity and inhibitors
    Int J Biochem Cell Biol39, 606-614. PubMed  Europe PubMed DOI  E  P
  59. Zhong,Q., Xu,L., Zhang,C. and Glatz,C.E.
    Purification of recombinant aprotinin from transgenic corn germ fraction using ion exchange and hydrophobic interaction chromatography
    Appl Microbiol Biotechnol76, 607-613. PubMed  Europe PubMed DOI  E
    60. 2006
  60. Dong,J. and Wu,W.T.
    Production process of recombinant aprotinin
    J China Pharm Univ37, 375-378.  E
  61. [YEAR:9-6-2006]Neuenschwander,P.F., Williamson,S.R., Nalian,A. and Baker-Deadmond,K.J.
    Heparin modulates the 99-loop of factor IXa: effects on reactivity with isolated Kunitz-type inhibitor domains
    J Biol Chem281, 23066-23074. PubMed  Europe PubMed DOI
  62. [YEAR:15-1-2006]Shiryaev,S.A., Ratnikov,B.I., Chekanov,A.V., Sikora,S., Rozanov,D.V., Godzik,A., Wang,J., Smith,J.W., Huang,Z., Lindberg,I., Samuel,M.A., Diamond,M.S. and Strongin,A.Y.
    Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase
    Biochem J393, 503-511. PubMed  Europe PubMed DOI  P  I
    63. 2005
  63. Beierlein,W., Scheule,A.M., Dietrich,W. and Ziemer,G.
    Forty years of clinical aprotinin use: a review of 124 hypersensitivity reactions
    Ann Thorac Surg79, 741-748. PubMed  Europe PubMed DOI  V
  64. Khan,T.A., Bianchi,C., Voisine,P., Sandmeyer,J., Feng,J. and Sellke,F.W.
    Aprotinin inhibits protease-dependent platelet aggregation and thrombosis
    Ann Thorac Surg79, 1545-1550. PubMed  Europe PubMed DOI
  65. Krowarsch,D., Zakrzewska,M., Smalas,A.O. and Otlewski,J.
    Structure-function relationships in serine protease-bovine pancreatic trypsin inhibitor interaction
    Protein Pept Lett12, 403-407. PubMed  Europe PubMed DOI
    66. 2004
  66. Apeler,H., Peters,J., Schroder,W., Schneider,K.H., Lemm,G., Hinz,V., Rossouw,G.J. and Dembowsky,K.
    Expression, purification, biochemical and pharmacological characterization of a recombinant aprotinin variant
    Arzneimittelforschung54, 483-497. PubMed  Europe PubMed DOI
  67. [YEAR:3-12-2004]Czapinska,H., Helland,R., Smalas,A.O. and Otlewski,J.
    Crystal structures of five bovine chymotrypsin complexes with P1 BPTI variants
    J Mol Biol344, 1005-1020. PubMed  Europe PubMed DOI  S
  68. [YEAR:10-2-2004]Filfil,R., Ratavosi,A. and Chalikian,T.V.
    Binding of bovine pancreatic trypsin inhibitor to trypsinogen: spectroscopic and volumetric studies
    Biochemistry43, 1315-1322. PubMed  Europe PubMed DOI
  69. Harmon,D.C., Ghori,K.G., Eustace,N.P., O'Callaghan,S.J., O'Donnell,A.P. and Shorten,G.D.
    Aprotinin decreases the incidence of cognitive deficit following CABG and cardiopulmonary bypass: a pilot randomized controlled study
    Can J Anaesth51, 1002-1009. PubMed  Europe PubMed DOI
    70. 2003
  70. Ascenzi,P., Bocedi,A., Bolognesi,M., Spallarossa,A., Coletta,M., De Cristofaro,R. and Menegatti,E.
    The bovine basic pancreatic trypsin inhibitor (Kunitz inhibitor): a milestone protein
    Curr Protein Pept Sci4, 231-251. PubMed  Europe PubMed DOI
  71. Bull,D.A. and Maurer,J.
    Aprotinin and preservation of myocardial function after ischemia-reperfusion injury
    Ann Thorac Surg75, S735-S739. PubMed  Europe PubMed DOI
  72. Frumento,R.J., O'Malley,C.M. and Bennett-Guerrero,E.
    Stroke after cardiac surgery: a retrospective analysis of the effect of aprotinin dosing regimens
    Ann Thorac Surg75, 479-483. PubMed  Europe PubMed DOI
  73. [YEAR:17-10-2003]Hanson,W.M., Beeser,S.A., Oas,T.G. and Goldenberg,D.P.
    Identification of a residue critical for maintaining the functional conformation of BPTI
    J Mol Biol333, 425-441. PubMed  Europe PubMed DOI
  74. Mossinger,H., Dietrich,W., Braun,S.L., Jochum,M., Meisner,H. and Richter,J.A.
    High-dose aprotinin reduces activation of hemostasis, allogeneic blood requirement, and duration of postoperative ventilation in pediatric cardiac surgery
    Ann Thorac Surg75, 430-437. PubMed  Europe PubMed DOI
  75. Wegner,J.
    Biochemistry of serine protease inhibitors and their mechanisms of action: a review
    J Extra Corpor Technol35, 326-338. PubMed  Europe PubMed
    76. 2002
  76. [YEAR:5-11-2002]Azzoni,A.R., Kusnadi,A.R., Miranda,E.A. and Nikolov,Z.L.
    Recombinant aprotinin produced in transgenic corn seed: extraction and purification studies
    Biotechnol Bioeng80, 268-276. PubMed  Europe PubMed DOI
  77. [YEAR:19-2-2002]Battiste,J.L., Li,R. and Woodward,C.
    A highly destabilizing mutation, G37A, of the bovine pancreatic trypsin inhibitor retains the average native conformation but greatly increases local flexibility
    Biochemistry41, 2237-2245. PubMed  Europe PubMed DOI
  78. Buczek,O., Koscielska-Kasprzak,K., Krowarsch,D., Dadlez,M. and Otlewski,J.
    Analysis of serine proteinase-inhibitor interaction by alanine shaving
    Protein Sci11, 806-819. PubMed  Europe PubMed DOI
  79. Buczek,O., Krowarsch,D. and Otlewski,J.
    Thermodynamics of single peptide bond cleavage in bovine pancreatic trypsin inhibitor (BPTI)
    Protein Sci11, 924-932. PubMed  Europe PubMed DOI
  80. Englberger,L., Markart,P., Eckstein,F.S., Immer,F.F., Berdat,P.A. and Carrel,T.P.
    Aprotinin reduces blood loss in off-pump coronary artery bypass (OPCAB) surgery
    Eur J Cardiothorac Surg22, 545-551. PubMed  Europe PubMed DOI
  81. [YEAR:27-12-2002]Hagihara,Y., Shiraki,K., Nakamura,T., Uegaki,K., Takagi,M., Imanaka,T. and Yumoto,N.
    Screening for stable mutants with amino acid pairs substituted for the disulfide bond between residues 14 and 38 of bovine pancreatic trypsin inhibitor (BPTI)
    J Biol Chem277, 51043-51048. PubMed  Europe PubMed DOI
  82. [YEAR:24-9-2002]Jaquiss,R.D., Ghanayem,N.S., Zacharisen,M.C., Mussatto,K.A., Tweddell,J.S. and Litwin,S.B.
    Safety of aprotinin use and re-use in pediatric cardiothoracic surgery
    Circulation106, I90-I94. PubMed  Europe PubMed
  83. Samama,C.M., Langeron,O., Rosencher,N., Capdevila,X., Rouche,P., Pegoix,M., Berniere,J. and Coriat,P.
    Aprotinin versus placebo in major orthopedic surgery: a randomized, double-blinded, dose-ranging study
    Anesth Analg95, 287-293. PubMed  Europe PubMed
    84. 2001
  84. Addlagatta,A., Krzywda,S., Czapinska,H., Otlewski,J. and Jaskolski,M.
    Ultrahigh-resolution structure of a BPTI mutant
    Acta Crystallogr D Biol Crystallogr57, 649-663. PubMed  Europe PubMed DOI  S
  85. [YEAR:30-11-2001]Botos,I., Wu,Z., Lu,W. and Wlodawer,A.
    Crystal structure of a cyclic form of bovine pancreatic trypsin inhibitor
    FEBS Lett509, 90-94. PubMed  Europe PubMed DOI  S  I
  86. [YEAR:26-10-2001]Bulaj,G. and Goldenberg,D.P.
    Mutational analysis of hydrogen bonding residues in the BPTI folding pathway
    J Mol Biol313, 639-656. PubMed  Europe PubMed DOI
    87. 2000
  87. Asimakopoulos,G., Taylor,K.M., Haskard,D.O. and Landis,R.C.
    Inhibition of neutrophil L-selectin shedding: a potential anti-inflammatory effect of aprotinin
    Perfusion15, 495-499. PubMed  Europe PubMed
  88. Czapinska,H., Otlewski,J., Krzywda,S., Sheldrick,G.M. and Jaskolski,M.
    High-resolution structure of bovine pancreatic trypsin inhibitor with altered binding loop sequence
    J Mol Biol295, 1237-1249. PubMed  Europe PubMed DOI  S
  89. [YEAR:4-8-2000]Grzesiak,A., Helland,R., Smalas,A.O., Krowarsch,D., Dadlez,M. and Otlewski,J.
    Substitutions at the P(1) position in BPTI strongly affect the association energy with serine proteinases
    J Mol Biol301, 205-217. PubMed  Europe PubMed DOI
  90. [YEAR:27-10-2000]Grzesiak,A., Krokoszynska,I., Krowarsch,D., Buczek,O., Dadlez,M. and Otlewski,J.
    Inhibition of six serine proteinases of the human coagulation system by mutants of bovine pancreatic trypsin inhibitor
    J Biol Chem275, 33346-33352. PubMed  Europe PubMed DOI
    91. 1999
  91. Hamiaux,C., Prange,T., Ries-Kautt,M., Ducruix,A., Lafont,S., Astier,J.P. and Veesler,S.
    The decameric structure of bovine pancreatic trypsin inhibitor (BPTI) crystallized from thiocyanate at 2.7 A resolution
    Acta Crystallogr D Biol Crystallogr55, 103-113. PubMed  Europe PubMed DOI  S
  92. [YEAR:16-4-1999]Helland,R., Otlewski,J., Sundheim,O., Dadlez,M. and Smalas,A.O.
    The crystal structures of the complexes between bovine beta-trypsin and ten P1 variants of BPTI
    J Mol Biol287, 923-942. PubMed  Europe PubMed DOI
  93. Iijima,R., Yamaguchi,S., Homma,K. and Natori,S.
    Stage-specific inhibition of Xenopus embryogenesis by aprotinin, a serine protease inhibitor
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