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Literature for inhibitor I02.001: aprotinin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature

(Topics flags: S Structure, P Specificity, K Knockout, E Expression, V Review, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. O'Neill,K.L., Zigmond,J.W. and Bergan,R.
    HSP90alpha and KLK6 Co-Regulate Stress-Induced Prostate Cancer Cell Motility
    bioRxiv (2025) PubMed  Europe PubMed DOI  PMC  EPMC  K  L
    2. 2024
  2. Nazir,F., Munir,I. and Yesiloz,G.
    A Microfluidics-Assisted Double-Barreled Nanobioconjugate Synthesis Introducing Aprotinin as a New Moonlight Nanocarrier Protein: Tested toward Physiologically Relevant 3D-Spheroid Models
    ACS Appl Mater Interfaces (2024) 16, 18311-18326. PubMed  Europe PubMed DOI
    3. 2023
  3. Ivachtchenko,A.V., Ivashchenko,A.A., Shkil,D.O. and Ivashchenko,I.A.
    Aprotinin-Drug against Respiratory Diseases
    Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC  V
  4. Roy,U.C. and Bandyopadhyay,P.
    Correlation between protein conformations and water structure and thermodynamics at high pressure: A molecular dynamics study of the Bovine Pancreatic Trypsin Inhibitor (BPTI) protein
    J Chem Phys (2023) 158, 095102-095102. PubMed  Europe PubMed DOI
    5. 2022
  5. Leppkes,J., Dimos,N., Loll,B., Hohmann,T., Dyrks,M., Wieseke,A., Keller,B.G. and Koksch,B.
    Fluorine-induced polarity increases inhibitory activity of BPTI towards chymotrypsin
    RSC Chem Biol (2022) 3, 773-782. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2020
  6. Bojkova,D., Bechtel,M., McLaughlin,K.M., McGreig,J.E., Klann,K., Bellinghausen,C., Rohde,G., Jonigk,D., Braubach,P., Ciesek,S., Munch,C., Wass,M.N., Michaelis,M. and Cinatl,J., Jr.
    Aprotinin Inhibits SARS-CoV-2 Replication
    Cells (2020) 9 PubMed  Europe PubMed DOI
  7. de Almeida,A.D., Silva,I.S., Fernandes-Braga,W., LimaFilho,A.C.M., Florentino,R.O.M., Barra,A., de Oliveira Andrade,L., Leite,M.F., Cassali,G.D. and Klein,A.
    A role for mast cells and mast cell tryptase in driving neutrophil recruitment in LPS-induced lung inflammation via protease-activated receptor 2 in mice
    Inflamm Res (2020) PubMed  Europe PubMed DOI
  8. Kahler,U., Kamenik,A.S., Waibl,F., Kraml,J. and Liedl,K.R.
    Protein-Protein Binding as a Two-Step Mechanism: Preselection of Encounter Poses during the Binding of BPTI and Trypsin
    Biophys J (2020) 119, 652-666. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Shi,J.Y., Pan,H.Y., Liu,K., Pan,M. and Si,G.J.
    Expression of ectopic trypsin in atherosclerotic plaques and the effects of aprotinin on plaque stability
    Arch Biochem Biophys (2020) 690, 108460-108460. PubMed  Europe PubMed DOI
    10. 2019
  10. Agic,D., Brkic,H., Kazazic,S., Tomic,A. and Abramic,M.
    Aprotinin interacts with substrate-binding site of human dipeptidyl peptidase III
    J Biomol Struct Dyn (2019) 37, 3596-3606. PubMed  Europe PubMed DOI
  11. Sasaki,Y., Sato,Y., Takahashi,T., Umetsu,M. and Iki,N.
    Capillary electrophoretic reactor for estimation of spontaneous dissociation rate of trypsin-aprotinin complex
    Anal Biochem (2019) 585, 113406-113406. PubMed  Europe PubMed DOI
  12. Soleyman-Jahi,S., Sadeghi,F., Afshari,Z., Barati,T., Ghasemi,S., Muhammadnejad,S., Amanpour,S. and Zendehdel,K.
    Anti-neoplastic effects of aprotinin on human breast cancer cell lines: in vitro study
    Adv Clin Exp Med (2019) 28, 151-157. PubMed  Europe PubMed DOI
    13. 2018
  13. Mousa,R., Lansky,S., Shoham,G. and Metanis,N.
    BPTI folding revisited: switching a disulfide into methylene thioacetal reveals a previously hidden path
    Chem Sci (2018) 9, 4814-4820. PubMed  Europe PubMed DOI  PMC  EPMC  S
    14. 2017
  14. Deloge,E., Amour,J., Provenchere,S., Rozec,B., Scherrer,B. and Ouattara,A.
    Aprotinin vs. tranexamic acid in isolated coronary artery bypass surgery: a multicentre observational study
    Eur J Anaesthesiol (2017) 34, 280-287. PubMed  Europe PubMed DOI  I
    15. 2016
  15. Ang,M.J., Lim,H.A., Poulsen,A., Wee,J.L., Ng,F.M., Joy,J., Hill,J. and Chia,C.S.
    Miniature bovine pancreatic trypsin inhibitors (m-BPTIs) of the West Nile virus NS2B-NS3 protease
    J Enzyme Inhib Med Chem (2016) 31, 194-200. PubMed  Europe PubMed DOI  I
    16. 2015
  16. Brannon,J.R., Burk,D.L., Leclerc,J.M., Thomassin,J.L., Portt,A., Berghuis,A.M., Gruenheid,S. and Le Moual,H.
    Inhibition of outer membrane proteases of the omptin family by aprotinin
    Infect Immun (2015) 83, 2300-2311. PubMed  Europe PubMed DOI
  17. Karasulu,H.Y., Oruc,N., Ustundag-Okur,N., Ilem Ozdemir,D., Ay Senyigit,Z., Barbet Yilmaz,F., Asikoglu,M., Ozkilic,H., Akcicek,E., Guneri,T. and Ozutemiz,O.
    Aprotinin revisited: formulation, characterization, biodistribution and therapeutic potential of new aprotinin microemulsion in acute pancreatitis
    J Drug Target (2015) 23, 525-537. PubMed  Europe PubMed DOI  U
  18. Royston,D.
    The current place of aprotinin in the management of bleeding
    Anaesthesia (2015) 70 Suppl 1, 46-49. PubMed  Europe PubMed DOI
  19. Xin,Y., Liu,L., Chen,B., Zhang,L. and Tong,Y.
    Affinity purification of aprotinin from bovine lung
    J Sep Sci (2015) 38, 1441-1448. PubMed  Europe PubMed DOI
  20. Ye,S., Loll,B., Berger,A.A., Mulow,U., Alings,C., Wahl,M.C. and Koksch,B.
    Fluorine teams up with water to restore inhibitor activity to mutant BPTI
    Chem Sci (2015) 6, 5246-5254. PubMed  Europe PubMed DOI  PMC  EPMC
    21. 2014
  21. Chen,W.N., Loscha,K.V., Nitsche,C., Graham,B. and Otting,G.
    The dengue virus NS2B-NS3 protease retains the closed conformation in the complex with BPTI
    FEBS Lett (2014) 588, 2206-2211. PubMed  Europe PubMed DOI
  22. Li,H., Zhu,L., Hou,S., Yang,J., Wang,J. and Liu,J.
    An inhibition model of BPTI to unlinked dengue virus NS2B-NS3 protease
    FEBS Lett (2014) 588, 2794-2799. PubMed  Europe PubMed DOI  S
    23. 2013
  23. Beckerman,Z., Shopen,Y., Alon,H., Cohen,O., Nir,R.R., Adler,Z. and Bolotin,G.
    Coronary artery bypass grafting after aprotinin: are we doing better?
    J Thorac Cardiovasc Surg (2013) 145, 243-248. PubMed  Europe PubMed DOI  U
  24. Ferraris,V.A.
    Facts, opinions, and conclusions: aprotinin brings out all of these
    J Thorac Cardiovasc Surg (2013) 145, 240-242. PubMed  Europe PubMed DOI
  25. Howell,N., Senanayake,E., Freemantle,N. and Pagano,D.
    Putting the record straight on aprotinin as safe and effective: results from a mixed treatment meta-analysis of trials of aprotinin
    J Thorac Cardiovasc Surg (2013) 145, 234-240. PubMed  Europe PubMed DOI
  26. Liu,F., Ye,M., Wang,C., Hu,Z., Zhang,Y., Qin,H., Cheng,K. and Zou,H.
    Polyacrylamide gel with switchable trypsin activity for analysis of proteins
    Anal Chem (2013) 85, 7024-7028. PubMed  Europe PubMed DOI
  27. Martin,K., Gertler,R., Macguill,M., Mayr,N.P., Hapfelmeier,A., Horer,J., Vogt,M., Tassani,P. and Wiesner,G.
    Replacement of aprotinin by epsilon-aminocaproic acid in infants undergoing cardiac surgery: Consequences for blood loss and outcome
    Br J Anaesth (2013) 110, 615-621. PubMed  Europe PubMed DOI  I
  28. McMullan,V. and Alston,R.P.
    III. Aprotinin and cardiac surgery: a sorry tale of evidence misused
    Br J Anaesth (2013) 110, 675-678. PubMed  Europe PubMed DOI  V
  29. Molnar,T., Voros,J., Szeder,B., Takats,K., Kardos,J., Katona,G. and Graf,L.
    Comparison of complexes formed by a crustacean and a vertebrate trypsin with bovine pancreatic trypsin inhibitor - the key to achieving extreme stability?
    FEBS J (2013) 280, 5750-5763. PubMed  Europe PubMed DOI
    30. 2012
  30. Deanda,A., Jr. and Spiess,B.D.
    Aprotinin revisited
    J Thorac Cardiovasc Surg (2012) 144, 998-1002. PubMed  Europe PubMed DOI  U
  31. Graham,E.M., Atz,A.M., Gillis,J., Desantis,S.M., Haney,A.L., Deardorff,R.L., Uber,W.E., Reeves,S.T., McGowan,F.X., Jr., Bradley,S.M. and Spinale,F.G.
    Differential effects of aprotinin and tranexamic acid on outcomes and cytokine profiles in neonates undergoing cardiac surgery
    J Thorac Cardiovasc Surg (2012) 143, 1069-1076. PubMed  Europe PubMed DOI  U  I
  32. Salameh,M.A., Soares,A.S., Alloy,A. and Radisky,E.S.
    Presence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitors
    Protein Sci (2012) 21, 1103-1112. PubMed  Europe PubMed DOI  S
    33. 2011
  33. Chang,J.Y.
    Distinct folding pathways of two homologous disulfide proteins: bovine pancreatic trypsin inhibitor and tick anticoagulant peptide
    Antioxid Redox Signal (2011) 14, 127-135. PubMed  Europe PubMed DOI
  34. Kawamura,K., Yamada,T., Kurihara,K., Tamada,T., Kuroki,R., Tanaka,I., Takahashi,H. and Niimura,N.
    X-ray and neutron protein crystallographic analysis of the trypsin-BPTI complex
    Acta Crystallogr D Biol Crystallogr (2011) 67, 140-148. PubMed  Europe PubMed DOI  S
  35. Trzebicki,J., Kosieradzki,M., Flakiewicz,E., Kuzminska,G., Wasiak,D., Pacholczyk,M., Lagiewska,B., Lisik,W., Kosson,D., Kulik,A., Chmura,A. and Lazowski,T.
    Detrimental effect of aprotinin ban on amount of blood loss during liver transplantation: single-center experience
    Transplant Proc (2011) 43, 1725-1727. PubMed  Europe PubMed DOI
  36. Viswanathan,A., Kuriakose,B., Bharadwaj,S. and Thomas,G.
    Expression of aprotinin in anther causes male sterility in tobacco var Petit Havana
    Plant Mol Biol Report (2011) 29, 825-834. DOI
  37. Zhirnov,O.P., Klenk,H.D. and Wright,P.F.
    Aprotinin and similar protease inhibitors as drugs against influenza
    Antiviral Res (2011) 92, 27-36. PubMed  Europe PubMed DOI
  38. Zhirnov,O.P., Matrosovich,T.Y., Matrosovich,M.N. and Klenk,H.D.
    Aprotinin, a protease inhibitor, suppresses proteolytic activation of pandemic H1N1v influenza virus
    Antiviral Chem Chemother (2011) 21, 245- DOI
    39. 2010
  39. Ide,M., Bolliger,D., Taketomi,T. and Tanaka,K.A.
    Lessons from the aprotinin saga: current perspective on antifibrinolytic therapy in cardiac surgery
    J Anesth (2010) 24, 96-106. PubMed  Europe PubMed DOI
  40. Kawamura,K., Yamada,T., Kurihara,K., Tamada,T., Kuroki,R., Tanaka,I., Takahashi,H. and Niimura,N.
    A preliminary neutron crystallography on the trypsin-bovine pancreatic trypsin inhibitor complex
    J Phys Conf Ser (2010) 251, 012033-012033. DOI  S
  41. McMullan,V. and Alston,R.P.
    The effect of the suspension of the license for aprotinin on the care of patients undergoing cardiac surgery: a survey of cardiac anesthesiologists' and surgeons' opinions in the united kingdom
    J Cardiothorac Vasc Anesth (2010) 24, 418-421. PubMed  Europe PubMed DOI  U
  42. Navaneetham,D., Sinha,D. and Walsh,P.N.
    Mechanisms and specificity of factor XIa and trypsin inhibition by protease nexin 2 and basic pancreatic trypsin inhibitor
    J Biochem (2010) 148, 467-479. PubMed  Europe PubMed DOI
  43. Salameh,M.A., Soares,A.S., Navaneetham,D., Sinha,D., Walsh,P.N. and Radisky,E.S.
    Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin
    J Biol Chem (2010) 285, 36884-36896. PubMed  Europe PubMed DOI
  44. Smith,M., Kocher,H.M. and Hunt,B.J.
    Aprotinin in severe acute pancreatitis
    Int J Clin Pract (2010) 64, 84-92. PubMed  Europe PubMed DOI  V
  45. Yang,I.S., Kim,T.G., Park,B.S., Cho,K.J., Lee,J.H., Park,Y. and Kim,K.H.
    Crystal structures of aprotinin and its complex with sucrose octasulfate reveal multiple modes of interactions with implications for heparin binding
    Biochem Biophys Res Commun (2010) 397, 429-435. PubMed  Europe PubMed DOI  S
    46. 2009
  46. Christy,L.A., Arvinth,S., Saravanakumar,M., Kanchana,M., Mukunthan,N., Srikanth,J., Thomas,G. and Subramonian,N.
    Engineering sugarcane cultivars with bovine pancreatic trypsin inhibitor (aprotinin) gene for protection against top borer (Scirpophaga excerptalis Walker)
    Plant Cell Rep (2009) 28, 175-184. PubMed  Europe PubMed DOI  E
  47. Dietrich,W.
    Aprotinin: 1 year on
    Curr Opin Anaesthesiol (2009) 22, 121-127. PubMed  Europe PubMed DOI
  48. Meta,A., Nakatake,H., Imamura,T., Nozaki,C. and Sugimura,K.
    High-yield production and characterization of biologically active recombinant aprotinin expressed in Saccharomyces cerevisiae
    Protein Expr Purif (2009) 66, 22-27. PubMed  Europe PubMed DOI  E
  49. Sun,Z., Lu,W., Jiang,A., Chen,J., Tang,F. and Liu,J.N.
    Expression, purification and characterization of aprotinin and a human analogue of aprotinin
    Protein Expr Purif (2009) 65, 238-243. PubMed  Europe PubMed DOI  E
  50. Yabe,K. and Koide,T.
    Inhibition of the 20S proteosome by a protein proteinase inhibitor: evidence that a natural serine proteinase inhibitor can inhibit a threonine proteinase
    J Biochem (2009) 145, 217-227. PubMed  Europe PubMed DOI
  51. Zakharova,E., Horvath,M.P. and Goldenberg,D.P.
    Structure of a serine protease poised to resynthesize a peptide bond
    Proc Natl Acad Sci U S A (2009) 106, 11034-11039. PubMed  Europe PubMed DOI  PMC  EPMC
    52. 2008
  52. de Cassia Dias,S., Sakauchi,D., Abreu,P.A., de Lima Netto,S., Iourtov,D., Raw,I. and Kubrusly,F.S.
    Purification and characterization of aprotinin from porcine lungs
    Biotechnol Lett (2008) 30, 807-812. PubMed  Europe PubMed DOI
  53. Getun,I.V., Brown,C.K., Tulla-Puche,J., Ohlendorf,D., Woodward,C. and Barany,G.
    Partially folded bovine pancreatic trypsin inhibitor analogues attain fully native structures when co-crystallized with S195A rat trypsin
    J Mol Biol (2008) 375, 812-823. PubMed  Europe PubMed DOI  S
  54. Salameh,M.A., Soares,A.S., Hockla,A. and Radisky,E.S.
    Structural basis for accelerated cleavage of bovine pancreatic trypsin inhibitor (BPTI) by human mesotrypsin
    J Biol Chem (2008) 283, 4115-4123. PubMed  Europe PubMed DOI
  55. Westaby,S.
    Aprotinin: twenty-five years of claim and counterclaim
    J Thorac Cardiovasc Surg (2008) 135, 487-491. PubMed  Europe PubMed DOI  V
  56. Yang,L., Dong,W., He,J., Ren,X. and Yan,W.
    Expression and purification of natural N-terminal recombinant bovine pancreatic trypsin inhibitor from Pichia pastoris
    Biol Pharm Bull (2008) 31, 1680-1685. PubMed  Europe PubMed DOI  E
  57. Zakharova,E., Horvath,M.P. and Goldenberg,D.P.
    Functional and structural roles of the Cys14-Cys38 disulfide of bovine pancreatic trypsin inhibitor
    J Mol Biol (2008) 382, 998-1013. PubMed  Europe PubMed DOI  PMC  EPMC
    58. 2007
  58. Hanson,W.M., Domek,G.J., Horvath,M.P. and Goldenberg,D.P.
    Rigidification of a flexible protease inhibitor variant upon binding to trypsin
    J Mol Biol (2007) 366, 230-243. PubMed  Europe PubMed DOI  PMC  EPMC
  59. Mueller,N.H., Yon,C., Ganesh,V.K. and Padmanabhan,R.
    Characterization of the West Nile virus protease substrate specificity and inhibitors
    Int J Biochem Cell Biol (2007) 39, 606-614. PubMed  Europe PubMed DOI  E  P
  60. Zhong,Q., Xu,L., Zhang,C. and Glatz,C.E.
    Purification of recombinant aprotinin from transgenic corn germ fraction using ion exchange and hydrophobic interaction chromatography
    Appl Microbiol Biotechnol (2007) 76, 607-613. PubMed  Europe PubMed DOI  E
    61. 2006
  61. Dong,J. and Wu,W.T.
    Production process of recombinant aprotinin
    J China Pharm Univ (2006) 37, 375-378.  E
  62. [YEAR:9-6-2006]Neuenschwander,P.F., Williamson,S.R., Nalian,A. and Baker-Deadmond,K.J.
    Heparin modulates the 99-loop of factor IXa: effects on reactivity with isolated Kunitz-type inhibitor domains
    J Biol Chem (9-6-2006) 281, 23066-23074. PubMed  Europe PubMed DOI  PMC  EPMC
  63. [YEAR:15-1-2006]Shiryaev,S.A., Ratnikov,B.I., Chekanov,A.V., Sikora,S., Rozanov,D.V., Godzik,A., Wang,J., Smith,J.W., Huang,Z., Lindberg,I., Samuel,M.A., Diamond,M.S. and Strongin,A.Y.
    Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase
    Biochem J (15-1-2006) 393, 503-511. PubMed  Europe PubMed DOI  PMC  EPMC  P  I
    64. 2005
  64. Beierlein,W., Scheule,A.M., Dietrich,W. and Ziemer,G.
    Forty years of clinical aprotinin use: a review of 124 hypersensitivity reactions
    Ann Thorac Surg (2005) 79, 741-748. PubMed  Europe PubMed DOI  V
  65. Khan,T.A., Bianchi,C., Voisine,P., Sandmeyer,J., Feng,J. and Sellke,F.W.
    Aprotinin inhibits protease-dependent platelet aggregation and thrombosis
    Ann Thorac Surg (2005) 79, 1545-1550. PubMed  Europe PubMed DOI
  66. Krowarsch,D., Zakrzewska,M., Smalas,A.O. and Otlewski,J.
    Structure-function relationships in serine protease-bovine pancreatic trypsin inhibitor interaction
    Protein Pept Lett (2005) 12, 403-407. PubMed  Europe PubMed DOI
    67. 2004
  67. Apeler,H., Peters,J., Schroder,W., Schneider,K.H., Lemm,G., Hinz,V., Rossouw,G.J. and Dembowsky,K.
    Expression, purification, biochemical and pharmacological characterization of a recombinant aprotinin variant
    Arzneimittelforschung (2004) 54, 483-497. PubMed  Europe PubMed DOI
  68. [YEAR:3-12-2004]Czapinska,H., Helland,R., Smalas,A.O. and Otlewski,J.
    Crystal structures of five bovine chymotrypsin complexes with P1 BPTI variants
    J Mol Biol (3-12-2004) 344, 1005-1020. PubMed  Europe PubMed DOI  S
  69. [YEAR:10-2-2004]Filfil,R., Ratavosi,A. and Chalikian,T.V.
    Binding of bovine pancreatic trypsin inhibitor to trypsinogen: spectroscopic and volumetric studies
    Biochemistry (10-2-2004) 43, 1315-1322. PubMed  Europe PubMed DOI
  70. Harmon,D.C., Ghori,K.G., Eustace,N.P., O'Callaghan,S.J., O'Donnell,A.P. and Shorten,G.D.
    Aprotinin decreases the incidence of cognitive deficit following CABG and cardiopulmonary bypass: a pilot randomized controlled study
    Can J Anaesth (2004) 51, 1002-1009. PubMed  Europe PubMed DOI
    71. 2003
  71. Ascenzi,P., Bocedi,A., Bolognesi,M., Spallarossa,A., Coletta,M., De Cristofaro,R. and Menegatti,E.
    The bovine basic pancreatic trypsin inhibitor (Kunitz inhibitor): a milestone protein
    Curr Protein Pept Sci (2003) 4, 231-251. PubMed  Europe PubMed DOI
  72. Bull,D.A. and Maurer,J.
    Aprotinin and preservation of myocardial function after ischemia-reperfusion injury
    Ann Thorac Surg (2003) 75, S735-S739. PubMed  Europe PubMed DOI
  73. Frumento,R.J., O'Malley,C.M. and Bennett-Guerrero,E.
    Stroke after cardiac surgery: a retrospective analysis of the effect of aprotinin dosing regimens
    Ann Thorac Surg (2003) 75, 479-483. PubMed  Europe PubMed DOI
  74. [YEAR:17-10-2003]Hanson,W.M., Beeser,S.A., Oas,T.G. and Goldenberg,D.P.
    Identification of a residue critical for maintaining the functional conformation of BPTI
    J Mol Biol (17-10-2003) 333, 425-441. PubMed  Europe PubMed DOI
  75. Mossinger,H., Dietrich,W., Braun,S.L., Jochum,M., Meisner,H. and Richter,J.A.
    High-dose aprotinin reduces activation of hemostasis, allogeneic blood requirement, and duration of postoperative ventilation in pediatric cardiac surgery
    Ann Thorac Surg (2003) 75, 430-437. PubMed  Europe PubMed DOI
  76. Wegner,J.
    Biochemistry of serine protease inhibitors and their mechanisms of action: a review
    J Extra Corpor Technol (2003) 35, 326-338. PubMed  Europe PubMed
    77. 2002
  77. [YEAR:5-11-2002]Azzoni,A.R., Kusnadi,A.R., Miranda,E.A. and Nikolov,Z.L.
    Recombinant aprotinin produced in transgenic corn seed: extraction and purification studies
    Biotechnol Bioeng (5-11-2002) 80, 268-276. PubMed  Europe PubMed DOI
  78. [YEAR:19-2-2002]Battiste,J.L., Li,R. and Woodward,C.
    A highly destabilizing mutation, G37A, of the bovine pancreatic trypsin inhibitor retains the average native conformation but greatly increases local flexibility
    Biochemistry (19-2-2002) 41, 2237-2245. PubMed  Europe PubMed DOI
  79. Buczek,O., Koscielska-Kasprzak,K., Krowarsch,D., Dadlez,M. and Otlewski,J.
    Analysis of serine proteinase-inhibitor interaction by alanine shaving
    Protein Sci (2002) 11, 806-819. PubMed  Europe PubMed DOI  PMC  EPMC
  80. Buczek,O., Krowarsch,D. and Otlewski,J.
    Thermodynamics of single peptide bond cleavage in bovine pancreatic trypsin inhibitor (BPTI)
    Protein Sci (2002) 11, 924-932. PubMed  Europe PubMed DOI  PMC  EPMC
  81. Englberger,L., Markart,P., Eckstein,F.S., Immer,F.F., Berdat,P.A. and Carrel,T.P.
    Aprotinin reduces blood loss in off-pump coronary artery bypass (OPCAB) surgery
    Eur J Cardiothorac Surg (2002) 22, 545-551. PubMed  Europe PubMed DOI
  82. [YEAR:27-12-2002]Hagihara,Y., Shiraki,K., Nakamura,T., Uegaki,K., Takagi,M., Imanaka,T. and Yumoto,N.
    Screening for stable mutants with amino acid pairs substituted for the disulfide bond between residues 14 and 38 of bovine pancreatic trypsin inhibitor (BPTI)
    J Biol Chem (27-12-2002) 277, 51043-51048. PubMed  Europe PubMed DOI
  83. [YEAR:24-9-2002]Jaquiss,R.D., Ghanayem,N.S., Zacharisen,M.C., Mussatto,K.A., Tweddell,J.S. and Litwin,S.B.
    Safety of aprotinin use and re-use in pediatric cardiothoracic surgery
    Circulation (24-9-2002) 106, I90-I94. PubMed  Europe PubMed
  84. Samama,C.M., Langeron,O., Rosencher,N., Capdevila,X., Rouche,P., Pegoix,M., Berniere,J. and Coriat,P.
    Aprotinin versus placebo in major orthopedic surgery: a randomized, double-blinded, dose-ranging study
    Anesth Analg (2002) 95, 287-293. PubMed  Europe PubMed
    85. 2001
  85. Addlagatta,A., Krzywda,S., Czapinska,H., Otlewski,J. and Jaskolski,M.
    Ultrahigh-resolution structure of a BPTI mutant
    Acta Crystallogr D Biol Crystallogr (2001) 57, 649-663. PubMed  Europe PubMed DOI  S
  86. [YEAR:30-11-2001]Botos,I., Wu,Z., Lu,W. and Wlodawer,A.
    Crystal structure of a cyclic form of bovine pancreatic trypsin inhibitor
    FEBS Lett (30-11-2001) 509, 90-94. PubMed  Europe PubMed DOI  S  I
  87. [YEAR:26-10-2001]Bulaj,G. and Goldenberg,D.P.
    Mutational analysis of hydrogen bonding residues in the BPTI folding pathway
    J Mol Biol (26-10-2001) 313, 639-656. PubMed  Europe PubMed DOI
    88. 2000
  88. Asimakopoulos,G., Taylor,K.M., Haskard,D.O. and Landis,R.C.
    Inhibition of neutrophil L-selectin shedding: a potential anti-inflammatory effect of aprotinin
    Perfusion (2000) 15, 495-499. PubMed  Europe PubMed
  89. Czapinska,H., Otlewski,J., Krzywda,S., Sheldrick,G.M. and Jaskolski,M.
    High-resolution structure of bovine pancreatic trypsin inhibitor with altered binding loop sequence
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