Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence Q9Y251

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
35	unknown peptidase	1-543	P	release of a signal peptide	NT	McKenzie et al., 2003
109	cathepsin L	36-543	P	normal turnover		Abboud-Jarrous et al., 2008
112	cathepsin L	36-543	P	normal turnover		Abboud-Jarrous et al., 2008
113	cathepsin L	36-543	P	normal turnover		Abboud-Jarrous et al., 2008
114	cathepsin L	36-543	P	normal turnover		Abboud-Jarrous et al., 2008
117	cathepsin L	36-543	P	normal turnover		Abboud-Jarrous et al., 2008
118	cathepsin L	36-543	P	normal turnover		Abboud-Jarrous et al., 2008
119	cathepsin L	36-543	P	normal turnover		Abboud-Jarrous et al., 2008
130	cathepsin L	36-543	P	normal turnover		Abboud-Jarrous et al., 2008
140	cathepsin L	36-543	P	normal turnover		Abboud-Jarrous et al., 2008
143	cathepsin L	36-543	P	normal turnover		Abboud-Jarrous et al., 2008
146	cathepsin L	36-543	P	normal turnover		Abboud-Jarrous et al., 2008
147	cathepsin L	36-543	P	normal turnover		Abboud-Jarrous et al., 2008
148	cathepsin L	36-543	P	normal turnover		Abboud-Jarrous et al., 2008
157	cathepsin L	36-543	P	normal turnover	NT	Abboud-Jarrous et al., 2008
338	lysyl endopeptidase (bacteria)	1-543	N		MS
368	lysyl endopeptidase (bacteria)	1-543	N		MS