Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence Q9P258

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
26	peptidyl-Lys metallopeptidase	1-522	N		MS
66	peptidyl-Lys metallopeptidase	1-522	N		MS
73	meprin alpha subunit	1-522	N		MS	Becker-Pauly et al., 2011
73	meprin beta subunit	1-522	N		MS	Becker-Pauly et al., 2011
77	granzyme A	1-522	N			Van Damme et al., 2010
77	trypsin 1	1-522	N		MS	Schilling & Overall, 2008
80	astacin	77-92	N		MS	Becker-Pauly et al., 2011
81	astacin	78-92	N		MS	Becker-Pauly et al., 2011
81	meprin alpha subunit	78-92	N		MS	Becker-Pauly et al., 2011
92	trypsin 1	1-522	N		MS	Schilling & Overall, 2008
194	trypsin 1	1-522	N		MS	Schilling & Overall, 2008
201	meprin beta subunit	198-211	N		MS	Becker-Pauly et al., 2011
211	trypsin 1	1-522	N		MS	Schilling & Overall, 2008
350	trypsin 1	1-522	N		MS	Schilling & Overall, 2008
361	trypsin 1	1-522	N		MS	Schilling & Overall, 2008
377	trypsin 1	1-522	N		MS	Schilling & Overall, 2008
384	trypsin 1	1-522	N		MS	Schilling & Overall, 2008