Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence Q13838

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-428	P		NT	<%Agarwal et al., 2012[]%>
15	meprin beta subunit	2-428	N		MS	Becker-Pauly et al., 2011
22	meprin beta subunit	2-428	N		MS	Becker-Pauly et al., 2011
32	peptidyl-Lys metallopeptidase	1-428	N		MS
36	trypsin 1	1-428	N		MS	Schilling & Overall, 2008
48	trypsin 1	1-428	N		MS	Schilling & Overall, 2008
52	peptidyl-Lys metallopeptidase	1-428	N		MS
66	cathepsin L	1-428	N		MS	Biniossek et al., 2011
190	peptidyl-Lys metallopeptidase	1-428	N		MS
191	trypsin 1	1-428	N		MS	Schilling & Overall, 2008
199	peptidyl-Lys metallopeptidase	1-428	N		MS
200	trypsin 1	1-428	N		MS	Schilling & Overall, 2008
241	trypsin 1	1-428	N		MS	Schilling & Overall, 2008
256	trypsin 1	1-428	N		MS	Schilling & Overall, 2008
384	trypsin 1	1-428	N		MS	Schilling & Overall, 2008
398	trypsin 1	1-428	N		MS	Schilling & Overall, 2008