Searches of the MEROPS database
Display Known Cleavages for a Protein
Please enter a UniProt accession (eg P05067):
Sequence Q13409
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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.
| Cleavage Site | Peptidase | Residue range | Cleavage type | Description | Evidence | Reference |
|---|---|---|---|---|---|---|
| 1 | unknown peptidase | 1-638 | P | release of an initiating methionine | MS | Van Damme P et al., 2005 |
| 43 | meprin alpha subunit | 1-638 | N | MS | Becker-Pauly et al., 2011 | |
| 43 | meprin beta subunit | 1-638 | N | MS | Becker-Pauly et al., 2011 | |
| 169 | trypsin 1 | 1-638 | N | MS | Schilling & Overall, 2008 | |
| 191 | trypsin 1 | 1-638 | N | MS | Schilling & Overall, 2008 | |
| 222 | HIV-1 retropepsin | 214-231 | N | MS | Schilling & Overall, 2008 | |
| 231 | trypsin 1 | 1-638 | N | MS | Schilling & Overall, 2008 | |
| 473 | cathepsin L | 466-483 | N | MS | Biniossek et al., 2011 | |
| 548 | trypsin 1 | 1-638 | N | MS | Schilling & Overall, 2008 | |
| 575 | trypsin 1 | 1-638 | N | MS | Schilling & Overall, 2008 | |
| 620 | matrix metallopeptidase-2 | 617-635 | N | MS | Schilling & Overall, 2008 | |
| 624 | cathepsin G | 617-635 | N | MS | Schilling & Overall, 2008 | |
| 635 | trypsin 1 | 1-638 | N | MS | Schilling & Overall, 2008 |
