Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P62917

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-257	P		NT	<%Agarwal et al., 2012[]%>
9	granzyme A	1-257	N			Van Damme et al., 2010
41	peptidyl-Lys metallopeptidase	1-257	N		MS
59	peptidyl-Lys metallopeptidase	1-257	N		MS
124	peptidyl-Lys metallopeptidase	1-257	N		MS
128	trypsin 1	2-257	N		MS	Schilling & Overall, 2008
131	matrix metallopeptidase-2	128-144	N		MS	Schilling & Overall, 2008
132	matrix metallopeptidase-2	128-144	N		MS	Schilling & Overall, 2008
133	cathepsin G	128-144	N		MS	Schilling & Overall, 2008
135	cathepsin B	129-144	N		MS	Biniossek et al., 2011
135	matrix metallopeptidase-2	128-144	N		MS	Schilling & Overall, 2008
144	trypsin 1	2-257	N		MS	Schilling & Overall, 2008
155	peptidyl-Lys metallopeptidase	1-257	N		MS
163	trypsin 1	2-257	N		MS	Schilling & Overall, 2008
164	matrix metallopeptidase-2	156-180	N		MS	Schilling & Overall, 2008
174	trypsin 1	2-257	N		MS	Schilling & Overall, 2008
180	chymotrypsin A (cattle-type)	2-257	N		MS	Schilling & Overall, 2008