Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P55884

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-814	P	release of an initiating methionine	MS
35	cathepsin L	17-57	N		MS	Biniossek et al., 2011
120	granzyme A	1-814	N			Van Damme et al., 2010
262	trypsin 1	1-814	N		MS	Schilling & Overall, 2008
271	trypsin 1	1-814	N		MS	Schilling & Overall, 2008
288	trypsin 1	1-814	N		MS	Schilling & Overall, 2008
303	trypsin 1	1-814	N		MS	Schilling & Overall, 2008
315	trypsin 1	1-814	N		MS	Schilling & Overall, 2008
332	trypsin 1	1-814	N		MS	Schilling & Overall, 2008
370	trypsin 1	1-814	N		MS	Schilling & Overall, 2008
386	trypsin 1	1-814	N		MS	Schilling & Overall, 2008
450	cathepsin L	441-460	N		MS	Biniossek et al., 2011
450	meprin alpha subunit	447-460	N		MS	Becker-Pauly et al., 2011
492	trypsin 1	1-814	N		MS	Schilling & Overall, 2008
501	trypsin 1	1-814	N		MS	Schilling & Overall, 2008
552	trypsin 1	1-814	N		MS	Schilling & Overall, 2008
562	trypsin 1	1-814	N		MS	Schilling & Overall, 2008