Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P49720

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-205	P		NT	<%Agarwal et al., 2012[]%>
27	trypsin 1	2-205	N		MS	Schilling & Overall, 2008
41	trypsin 1	2-205	N		MS	Schilling & Overall, 2008
48	trypsin 1	2-205	N		MS	Schilling & Overall, 2008
55	matrix metallopeptidase-2	48-66	N		MS	Schilling & Overall, 2008
66	trypsin 1	2-205	N		MS	Schilling & Overall, 2008
67	chymotrypsin A (cattle-type)	2-205	N		MS	Schilling & Overall, 2008
69	chymotrypsin A (cattle-type)	2-205	N		MS	Schilling & Overall, 2008
70	trypsin 1	2-205	N		MS	Schilling & Overall, 2008
77	trypsin 1	2-205	N		MS	Schilling & Overall, 2008
99	trypsin 1	2-205	N		MS	Schilling & Overall, 2008
115	trypsin 1	2-205	N		MS	Schilling & Overall, 2008
181	cathepsin B	178-192	N		MS	Biniossek et al., 2011
182	matrix metallopeptidase-2	177-192	N		MS	Schilling & Overall, 2008
192	trypsin 1	2-205	N		MS	Schilling & Overall, 2008