Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P29288

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
22	unknown peptidase	1-327	P	release of a signal peptide	NT	Ek-Rylander et al., 1991
163	cathepsin K	23-327	P		NT	Ljusberg et al., 2005
164	cathepsin L	23-327	P		NT	Ljusberg et al., 2005
166	cathepsin L	23-327	P		NT	Ljusberg et al., 2005
171	cathepsin L	23-327	P		NT	Ljusberg et al., 2005
181	cathepsin L	23-327	P		NT	Ljusberg et al., 2005
181	cathepsin K	23-327	P		NT	Ljusberg et al., 2005
183	cathepsin L	23-327	P		NT	Ljusberg et al., 2005
183	cathepsin K	23-327	P		NT	Ljusberg et al., 2005