Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P22492

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-207	P		NT	<%Agarwal et al., 2012[]%>
27	peptidyl-Lys metallopeptidase	1-207	N		MS
65	matrix metallopeptidase-2	64-75	N		MS	Schilling & Overall, 2008
66	peptidyl-Lys metallopeptidase	1-207	N		MS
67	trypsin 1	2-207	N		MS	Schilling & Overall, 2008
68	trypsin 1	2-207	N		MS	Schilling & Overall, 2008
70	cathepsin G	68-79	N		MS	Schilling & Overall, 2008
71	cathepsin B	69-79	N		MS	Biniossek et al., 2011
71	astacin	68-83	N		MS	Becker-Pauly et al., 2011
75	chymotrypsin A (cattle-type)	2-207	N		MS	Schilling & Overall, 2008
78	peptidyl-Lys metallopeptidase	1-207	N		MS
79	trypsin 1	2-207	N		MS	Schilling & Overall, 2008