Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P16402

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-221	P		NT	<%Agarwal et al., 2012[]%>
34	trypsin 1	2-221	N		MS	Schilling & Overall, 2008
35	trypsin 1	2-221	N		MS	Schilling & Overall, 2008
43	matrix metallopeptidase-2	7-60	N		MS	Schilling & Overall, 2008
47	trypsin 1	2-221	N		MS	Schilling & Overall, 2008
48	matrix metallopeptidase-2	44-60	N		MS	Schilling & Overall, 2008
55	trypsin 1	2-221	N		MS	Schilling & Overall, 2008
60	chymotrypsin A (cattle-type)	2-221	N		MS	Schilling & Overall, 2008
62	matrix metallopeptidase-2	61-72	N		MS	Schilling & Overall, 2008
64	trypsin 1	2-221	N		MS	Schilling & Overall, 2008
65	trypsin 1	2-221	N		MS	Schilling & Overall, 2008
67	cathepsin G	65-76	N		MS	Schilling & Overall, 2008
72	chymotrypsin A (cattle-type)	2-221	N		MS	Schilling & Overall, 2008
75	peptidyl-Lys metallopeptidase	1-221	N		MS
76	trypsin 1	2-221	N		MS	Schilling & Overall, 2008
87	matrix metallopeptidase-2	85-106	N		MS	Schilling & Overall, 2008
106	chymotrypsin A (cattle-type)	2-221	N		MS	Schilling & Overall, 2008
111	granzyme A	1-221	N			Van Damme et al., 2010