Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P07858

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
17	unknown peptidase	1-339	P		NT	<%Agarwal et al., 2012[]%>
27	meprin alpha subunit	80-333	N		MS	Becker-Pauly et al., 2011
27	meprin beta subunit	1-339	N		MS	Becker-Pauly et al., 2011
57	cathepsin B	18-333	P	release of an activation peptide		Quraishi & Storer, 2001
59	cathepsin B	18-333	P	release of an activation peptide		Quraishi & Storer, 2001
79	unknown peptidase	1-339	P		NT	<%Agarwal et al., 2012[]%>
107	matrix metallopeptidase-2	100-120	N		MS	Schilling & Overall, 2008
110	cathepsin B	101-120	N		MS	Biniossek et al., 2011
120	trypsin 1	80-333	N		MS	Schilling & Overall, 2008
126	unknown peptidase	1-339	P		NT	<%Agarwal et al., 2012[]%>
128	unknown peptidase	1-339	P		NT	<%Agarwal et al., 2012[]%>
192	cathepsin L	181-206	N		MS	Biniossek et al., 2011
320	matrix metallopeptidase-2	314-331	N		MS	Schilling & Overall, 2008
324	cathepsin B	315-332	N		MS	Biniossek et al., 2011
331	trypsin 1	80-333	N		MS	Schilling & Overall, 2008
333	unknown peptidase	1-339	P		NT	<%Agarwal et al., 2012[]%>