Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P01068

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
19	signalase (animal) 21 kDa component	1-246	P	release of a signal peptide	NT	Reddy et al., 1975
35	unknown peptidase	1-246	P		NT	<%Agarwal et al., 2012[]%>
95	unknown peptidase	1-246	P		NT	<%Agarwal et al., 2012[]%>
105	chymotrypsin A (cattle-type)	96-152	N			Sawano et al., 2005
106	stem bromelain	96-152	P			Sawano et al., 2005
106	trypsin 1	96-152	N			Sawano et al., 2005
107	stem bromelain	96-152	P			Sawano et al., 2005
108	stem bromelain	96-152	P			Sawano et al., 2005
109	stem bromelain	96-152	P			Sawano et al., 2005
110	stem bromelain	96-152	P			Sawano et al., 2005
111	unknown peptidase	1-246	P		NT	<%Agarwal et al., 2012[]%>
171	unknown peptidase	1-246	P		NT	<%Agarwal et al., 2012[]%>
187	unknown peptidase	1-246	P		NT	<%Agarwal et al., 2012[]%>
228	unknown peptidase	1-246	P		NT	<%Agarwal et al., 2012[]%>