Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P00334

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-256	P		NT	<%Agarwal et al., 2012[]%>
4	thermolysin	1-256	N			Thatcher et al., 1980
5	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
7	pepsin A	1-256	N			Thatcher et al., 1980
8	trypsin 1	1-256	N			Thatcher et al., 1980
8	PofibS endopeptidase (Philodryas olfersii)	1-256	N			Thatcher et al., 1979
9	pepsin A	1-256	N			Thatcher et al., 1980
12	pepsin A	1-256	N			Thatcher et al., 1980
12	thermolysin	1-256	N			Thatcher et al., 1980
12	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
18	pepsin A	1-256	N			Thatcher et al., 1980
18	thermolysin	1-256	N			Thatcher et al., 1980
20	pepsin A	1-256	N			Thatcher et al., 1980
20	thermolysin	1-256	N			Thatcher et al., 1980
21	pepsin A	1-256	N			Thatcher et al., 1980
21	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
25	trypsin 1	1-256	N			Thatcher et al., 1980
26	thermolysin	1-256	N			Thatcher et al., 1980
27	pepsin A	1-256	N			Thatcher et al., 1980
27	thermolysin	1-256	N			Thatcher et al., 1980
27	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
28	pepsin A	1-256	N			Thatcher et al., 1980
28	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1980
29	trypsin 1	1-256	N			Thatcher et al., 1980
29	PofibS endopeptidase (Philodryas olfersii)	1-256	N			Thatcher et al., 1979
30	pepsin A	1-256	N			Thatcher et al., 1980
30	trypsin 1	1-256	N			Thatcher et al., 1980
31	thermolysin	1-256	N			Thatcher et al., 1980
32	pepsin A	1-256	N			Thatcher et al., 1980
32	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
33	trypsin 1	1-256	N			Thatcher et al., 1980
33	PofibS endopeptidase (Philodryas olfersii)	1-256	N			Thatcher et al., 1979
34	pepsin A	1-256	N			Thatcher et al., 1980
34	thermolysin	1-256	N			Thatcher et al., 1980
35	pepsin A	1-256	N			Thatcher et al., 1980
35	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
37	thermolysin	1-256	N			Thatcher et al., 1980
38	pepsin A	1-256	N			Thatcher et al., 1980
39	pepsin A	1-256	N			Thatcher et al., 1980
44	thermolysin	1-256	N			Thatcher et al., 1980
46	pepsin A	1-256	N			Thatcher et al., 1980
46	thermolysin	1-256	N			Thatcher et al., 1980
47	pepsin A	1-256	N			Thatcher et al., 1980
49	pepsin A	1-256	N			Thatcher et al., 1980
50	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
51	pepsin A	1-256	N			Thatcher et al., 1980
51	trypsin 1	1-256	N			Thatcher et al., 1979
52	pepsin A	1-256	N			Thatcher et al., 1980
52	thermolysin	1-256	N			Thatcher et al., 1980
56	trypsin 1	1-256	N			Thatcher et al., 1980
59	thermolysin	1-256	N			Thatcher et al., 1980
60	thermolysin	1-256	N			Thatcher et al., 1980
61	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
64	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
65	thermolysin	1-256	N			Thatcher et al., 1980
69	thermolysin	1-256	N			Thatcher et al., 1980
72	pepsin A	1-256	N			Thatcher et al., 1980
73	pepsin A	1-256	N			Thatcher et al., 1980
75	pepsin A	1-256	N			Thatcher et al., 1980
75	thermolysin	1-256	N			Thatcher et al., 1980
75	trypsin 1	1-256	N			Thatcher et al., 1980
76	thermolysin	1-256	N			Thatcher et al., 1980
76	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
77	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
78	trypsin 1	1-256	N			Thatcher et al., 1980
81	pepsin A	1-256	N			Thatcher et al., 1980
81	thermolysin	1-256	N			Thatcher et al., 1980
81	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
83	thermolysin	1-256	N			Thatcher et al., 1980
84	pepsin A	1-256	N			Thatcher et al., 1980
84	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
85	trypsin 1	1-256	N			Thatcher et al., 1980
86	thermolysin	1-256	N			Thatcher et al., 1980
87	pepsin A	1-256	N			Thatcher et al., 1980
88	pepsin A	1-256	N			Thatcher et al., 1980
88	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
90	thermolysin	1-256	N			Thatcher et al., 1980
90	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
97	pepsin A	1-256	N			Thatcher et al., 1980
97	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
101	pepsin A	1-256	N			Thatcher et al., 1980
101	thermolysin	1-256	N			Thatcher et al., 1980
104	pepsin A	1-256	N			Thatcher et al., 1980
104	trypsin 1	1-256	N			Thatcher et al., 1979
107	pepsin A	1-256	N			Thatcher et al., 1980
107	thermolysin	1-256	N			Thatcher et al., 1980
109	thermolysin	1-256	N			Thatcher et al., 1980
110	thermolysin	1-256	N			Thatcher et al., 1980
110	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
112	thermolysin	1-256	N			Thatcher et al., 1980
113	pepsin A	1-256	N			Thatcher et al., 1980
113	thermolysin	1-256	N			Thatcher et al., 1980
113	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
116	pepsin A	1-256	N			Thatcher et al., 1980
117	pepsin A	1-256	N			Thatcher et al., 1980
118	thermolysin	1-256	N			Thatcher et al., 1980
119	pepsin A	1-256	N			Thatcher et al., 1980
120	thermolysin	1-256	N			Thatcher et al., 1980
122	thermolysin	1-256	N			Thatcher et al., 1980
123	pepsin A	1-256	N			Thatcher et al., 1980
123	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
124	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
133	thermolysin	1-256	N			Thatcher et al., 1980
134	thermolysin	1-256	N			Thatcher et al., 1980
137	pepsin A	1-256	N			Thatcher et al., 1980
137	thermolysin	1-256	N			Thatcher et al., 1980
143	thermolysin	1-256	N			Thatcher et al., 1980
144	pepsin A	1-256	N			Thatcher et al., 1980
144	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
146	thermolysin	1-256	N			Thatcher et al., 1980
149	thermolysin	1-256	N			Thatcher et al., 1980
151	thermolysin	1-256	N			Thatcher et al., 1980
153	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
154	thermolysin	1-256	N			Thatcher et al., 1980
157	pepsin A	1-256	N			Thatcher et al., 1980
157	trypsin 1	1-256	N			Thatcher et al., 1979
160	thermolysin	1-256	N			Thatcher et al., 1980
162	thermolysin	1-256	N			Thatcher et al., 1980
163	pepsin A	1-256	N			Thatcher et al., 1980
163	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
164	thermolysin	1-256	N			Thatcher et al., 1980
166	thermolysin	1-256	N			Thatcher et al., 1980
167	pepsin A	1-256	N			Thatcher et al., 1980
167	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
169	thermolysin	1-256	N			Thatcher et al., 1980
169	trypsin 1	1-256	N			Thatcher et al., 1979
170	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
175	thermolysin	1-256	N			Thatcher et al., 1980
177	thermolysin	1-256	N			Thatcher et al., 1980
178	pepsin A	1-256	N			Thatcher et al., 1980
179	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
187	trypsin 1	1-256	N			Thatcher et al., 1979
189	pepsin A	1-256	N			Thatcher et al., 1980
189	thermolysin	1-256	N			Thatcher et al., 1980
190	thermolysin	1-256	N			Thatcher et al., 1980
190	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
193	thermolysin	1-256	N			Thatcher et al., 1980
194	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
196	pepsin A	1-256	N			Thatcher et al., 1980
198	pepsin A	1-256	N			Thatcher et al., 1980
198	thermolysin	1-256	N			Thatcher et al., 1980
203	thermolysin	1-256	N			Thatcher et al., 1980
203	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
207	thermolysin	1-256	N			Thatcher et al., 1980
207	trypsin 1	1-256	N			Thatcher et al., 1980
208	pepsin A	1-256	N			Thatcher et al., 1980
208	thermolysin	1-256	N			Thatcher et al., 1980
208	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
209	pepsin A	1-256	N			Thatcher et al., 1980
216	thermolysin	1-256	N			Thatcher et al., 1980
218	pepsin A	1-256	N			Thatcher et al., 1980
222	thermolysin	1-256	N			Thatcher et al., 1980
223	thermolysin	1-256	N			Thatcher et al., 1980
223	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
225	trypsin 1	1-256	N			Thatcher et al., 1980
226	pepsin A	1-256	N			Thatcher et al., 1980
226	thermolysin	1-256	N			Thatcher et al., 1980
228	thermolysin	1-256	N			Thatcher et al., 1980
229	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
232	thermolysin	1-256	N			Thatcher et al., 1980
234	thermolysin	1-256	N			Thatcher et al., 1980
236	thermolysin	1-256	N			Thatcher et al., 1980
236	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
237	trypsin 1	1-256	N			Thatcher et al., 1980
239	thermolysin	1-256	N			Thatcher et al., 1980
242	thermolysin	1-256	N			Thatcher et al., 1980
243	pepsin A	1-256	N			Thatcher et al., 1980
243	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
244	pepsin A	1-256	N			Thatcher et al., 1980
245	thermolysin	1-256	N			Thatcher et al., 1980
247	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
248	thermolysin	1-256	N			Thatcher et al., 1980
248	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979
250	trypsin 1	1-256	N			Thatcher et al., 1979
251	thermolysin	1-256	N			Thatcher et al., 1980
251	chymotrypsin A (cattle-type)	1-256	N			Thatcher et al., 1979