Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Sequence P00100

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Reference
6	chymotrypsin A (cattle-type)	1-82	N	Ambler et al., 1973
7	chymotrypsin A (cattle-type)	1-82	N	Ambler et al., 1973
8	trypsin 1	1-82	N	Ambler et al., 1973
16	chymotrypsin A (cattle-type)	1-82	N	Ambler et al., 1973
21	trypsin 1	1-82	N	Ambler et al., 1973
22	chymotrypsin A (cattle-type)	1-82	N	Ambler et al., 1973
28	trypsin 1	1-82	N	Ambler et al., 1973
33	trypsin 1	1-82	N	Ambler et al., 1973
34	chymotrypsin A (cattle-type)	1-82	N	Ambler et al., 1973
38	trypsin 1	1-82	N	Ambler et al., 1973
42	trypsin 1	1-82	N	Ambler et al., 1973
44	chymotrypsin A (cattle-type)	1-82	N	Ambler et al., 1973
49	chymotrypsin A (cattle-type)	1-82	N	Ambler et al., 1973
49	trypsin 1	1-82	N	Ambler et al., 1973
53	chymotrypsin A (cattle-type)	1-82	N	Ambler et al., 1973
56	chymotrypsin A (cattle-type)	1-82	N	Ambler et al., 1973
61	chymotrypsin A (cattle-type)	1-82	N	Ambler et al., 1973
65	chymotrypsin A (cattle-type)	1-82	N	Ambler et al., 1973
70	chymotrypsin A (cattle-type)	1-82	N	Ambler et al., 1973
72	chymotrypsin A (cattle-type)	1-82	N	Ambler et al., 1973
74	chymotrypsin A (cattle-type)	1-82	N	Ambler et al., 1973
77	chymotrypsin A (cattle-type)	1-82	N	Ambler et al., 1973
79	chymotrypsin A (cattle-type)	1-82	N	Ambler et al., 1973